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573098 JAK2 Inhibitor III, SD-1029

The JAK2 Inhibitor III, SD-1029, also referenced under CAS 118372-34-2, controls the biological activity of JAK2.

JAK2 Inhibitor III, SD-1029 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 9-(3,4-Dichlorophenyl)-2,7-bis(dimethylaminomethyl)-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione, 2HBr, NSC 371488

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573098
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
118372-34-2C₂₅H₃₀Cl₂N₂O₃ • 2HBr

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573098-10MG
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      Description
      OverviewA cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor. It exhibits much less effect on the cellular phosphorylation levels of Jak1 and Src and shows no significant inhibition towards a panel of 49 other protein kinases in cell-free kinase assays at a concentration of 10 µM. Effectively inhibits cell proliferation in JAK-activated BA/F3 cell lines as well as phosphorylation and nuclear translocation of cellular Stat3.
      Catalogue Number573098
      Brand Family Calbiochem®
      Synonyms9-(3,4-Dichlorophenyl)-2,7-bis(dimethylaminomethyl)-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione, 2HBr, NSC 371488
      References
      ReferencesDuan, Z., et al. 2006. Clin. Cancer Res. 12, 6844.
      Product Information
      CAS number118372-34-2
      FormOff-white solid
      Hill FormulaC₂₅H₃₀Cl₂N₂O₃ • 2HBr
      Chemical formulaC₂₅H₃₀Cl₂N₂O₃ • 2HBr
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥80% by HPLC (sum of isomers)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      573098-10MG 04055977266399

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      JAK2 Inhibitor III, SD-1029 SDS

      Title

      Safety Data Sheet (SDS) 

      JAK2 Inhibitor III, SD-1029 Certificates of Analysis

      TitleLot Number
      573098

      References

      Reference overview
      Duan, Z., et al. 2006. Clin. Cancer Res. 12, 6844.

      Technical Info

      Title
      JAK/STAT Signaling Research Focus
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms9-(3,4-Dichlorophenyl)-2,7-bis(dimethylaminomethyl)-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione, 2HBr, NSC 371488
      DescriptionA cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor. It exhibits much less effect on the cellular phosphorylation levels of JAK1 and Src and shows no significant inhibition towards a panel of 49 other protein kinases in cell-free kinase assays at a concentration of 10 µM. Effectively inhibits cell proliferation in JAK-activated BA/F3 cell lines as well as phosphorylation and nuclear translocation of cellular Stat3.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number118372-34-2
      Chemical formulaC₂₅H₃₀Cl₂N₂O₃ • 2HBr
      Structure formulaStructure formula
      Purity≥80% by HPLC (sum of isomers)
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesDuan, Z., et al. 2006. Clin. Cancer Res. 12, 6844.