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573095 STAT3 Inhibitor Peptide

STAT3 Inhibitor Peptide MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-PpYLKTK-OH, STAT3 Inhibitor I

Primary Target: STAT3
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      Overview

      Key Spec Table

      Empirical Formula
      C₃₈H₆₃N₈O₁₃P
      Description
      Overview

      This product has been discontinued.



      A Stat3-SH2 domain binding phosphopeptide that acts as a selective inhibitor of Stat3 (signal transducers and activators of transcription 3) signaling with a DB50 of 235 µM (concentration of peptide at which DNA-binding activity is inhibited by 50%). Significantly lowers the DNA-binding activity of Stat3 by forming an inactive Stat3:peptide complex and reduces the levels of active Stat3:Stat3 dimers that can bind DNA. Displays greater affinity for Stat3, and to a lesser extent Stat1, over Stat5.
      Supplied as a trifluoroacetate salt.
      Catalogue Number573095
      Brand Family Calbiochem®
      SynonymsAc-PpYLKTK-OH, STAT3 Inhibitor I
      References
      ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₃₈H₆₃N₈O₁₃P
      Chemical formulaC₃₈H₆₃N₈O₁₃P
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary TargetSTAT3
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Pro-Tyr(PO₃H₂)-Leu-Lys-Thr-Lys-OH
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      573095 0