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570250 STO-609 - CAS 52029-86-4 - Calbiochem

A cell-permeable and reversible naphthoyl fused benzimidazole compound that acts as a highly selective, potent, ATP-competitive inhibitor of Ca2+/CaM-KK.

STO-609 - CAS 52029-86-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7H-Benz[de]benzimidazo[2,1-a]isoquinoline-7-one-3-carboxylic Acid, Acetate, 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid, Acetate

Primary Target: CaM-KKα
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      52029-86-4C₁₉H₁₀N₂O₃ • CH₃CO₂H
      Description
      OverviewA cell-permeable and reversible naphthoyl fused benzimidazole compound that acts as a highly selective, potent, ATP-competitive inhibitor of Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) [IC50 = 120 ng/ml and 40 ng/ml for CaM-KKα and CaM-KKβ isoforms, respectively]. Binds to the catalytic domain of CaM-KK, and inhibits autophosphorylation. Does not significantly affect the activities of CaM-KII, MLCK (IC50 = ~10 µg/ml), CaM-KI, CaM-KIV, PKA, PKC, and p42 MAP kinase (IC50 >10 µg/ml). Has also been reported to inhibit phosphorylation of AMP-activated protein kinase (AMPK).
      Catalogue Number570250
      Brand Family Calbiochem®
      Synonyms7H-Benz[de]benzimidazo[2,1-a]isoquinoline-7-one-3-carboxylic Acid, Acetate, 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid, Acetate
      References
      ReferencesLevine, Y., et al. 2007. J. Biol. Chem. 282, 20351.
      Tokumitsu, H., et al. 2003. J. Biol. Chem. 278, 10908.
      Tokumitsu, H., et al. 2002. J. Biol. Chem. 277, 15813.
      Product Information
      CAS number52029-86-4
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₉H₁₀N₂O₃ • CH₃CO₂H
      Chemical formulaC₁₉H₁₀N₂O₃ • CH₃CO₂H
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCaM-KKα
      Primary Target IC<sub>50</sub>120 ng/ml and 40 ng/ml for CaM-KKα and CaM-KKβ isoforms, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      570250 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      STO-609 - CAS 52029-86-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      STO-609 - CAS 52029-86-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      570250

      References

      Reference overview
      Levine, Y., et al. 2007. J. Biol. Chem. 282, 20351.
      Tokumitsu, H., et al. 2003. J. Biol. Chem. 278, 10908.
      Tokumitsu, H., et al. 2002. J. Biol. Chem. 277, 15813.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-November-2009 RFH
      Synonyms7H-Benz[de]benzimidazo[2,1-a]isoquinoline-7-one-3-carboxylic Acid, Acetate, 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid, Acetate
      DescriptionA cell-permeable and reversible napthoyl-fused benzimidazole compound that acts as a highly selective, potent, ATP-competitive inhibitor of Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) (IC50 = 120 ng/ml and 40 ng/ml for CaM-KKα and CaM-KKβ isoforms, respectively). Reported to bind to the catalytic domain of CaM-KK, and inhibit autophosphorylation. Does not significantly affect the activities of CaM-KII, MLCK (IC50 ~10 µg/ml), CaM-KI, CaM-KIV, PKA, PKC and p42 MAP kinase (IC50 >10 µg/ml). Has also been reported to inhibit phosphorylation of AMP-activated protein kinase (AMPK).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number52029-86-4
      Chemical formulaC₁₉H₁₀N₂O₃ • CH₃CO₂H
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or 100 mM NaOH (20 mg/ml). May require warming to acheive complete solubilization in DMSO.
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLevine, Y., et al. 2007. J. Biol. Chem. 282, 20351.
      Tokumitsu, H., et al. 2003. J. Biol. Chem. 278, 10908.
      Tokumitsu, H., et al. 2002. J. Biol. Chem. 277, 15813.