Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
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Buffer Detection Kit for Magnetic Beads
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Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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567310
Sigma-AldrichSKF-96365, Hydrochloride - CAS 130495-35-1 - Calbiochem
Inhibits receptor-mediated Ca2+ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca2+ release.
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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
Inhibits receptor-mediated Ca2+ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca2+ release. Also inhibits voltage-gated Ca2+ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.
SKF-96365, Hydrochloride - CAS 130495-35-1 - Calbiochem Certificates of Analysis
Title
Lot Number
567310
References
Reference overview
Leung, Y.-M., et al. 1996. Biochem. Pharmacol.51, 605. Schwartz, G., et al. 1994. Cell Calcium15, 45. Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357. Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539. Blayney, L.M., et al. 1991. Biochem. J. 273, 803. Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351. Merritt, J.E., et al. 1990. Biochem. J.271, 515.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Inhibits receptor-mediated Ca2+ entry in stimulated platelets (IC50 = 8-12 µM in intact platelets), neutrophils, and endothelial cells (IC50 = 30 µM for human endothelial cells) at concentrations that do not affect internal Ca2+ release. Also inhibits voltage-gated Ca2+ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.
Form
White solid
CAS number
130495-35-1
Chemical formula
C₂₂H₂₆N₂O₃ . HCl
Structure formula
Purity
≥98% by HPLC
Solubility
H₂O (2 mg/ml)
Storage
+15°C to +30°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Irritant
References
Leung, Y.-M., et al. 1996. Biochem. Pharmacol.51, 605. Schwartz, G., et al. 1994. Cell Calcium15, 45. Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357. Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539. Blayney, L.M., et al. 1991. Biochem. J. 273, 803. Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351. Merritt, J.E., et al. 1990. Biochem. J.271, 515.
