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531042 Estrogen Receptor Antagonist, ICI 182,780 - CAS 129453-61-8 - Calbiochem

A cell-permeable estrogen antagonist. More effective than tamoxifen in reducing estrogen receptors in breast tumor cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GPR30 Agonist, ICI 182,780, ICI 182780, ICI182780

Primary Target: ER
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531042
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
129453-61-8C₃₂H₄₇F₅O₃S

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      		 Glass bottle 10 mg
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      Description
      OverviewA cell-permeable estradiol derivative that acts as an estrogen antagonist and down-regulates estrogen receptors without affecting estrogen receptor-mediated progesterone receptor expression. Hence, it lacks estrogen agonist activity. Shown to be more effective than tamoxifen in reducing estrogen receptors in breast tumor cells. Suppresses the growth of MCF-7 xenografts in mice for twice as long as tamoxifen and delays tumor growth.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531042
      Brand Family Calbiochem®
      SynonymsGPR30 Agonist, ICI 182,780, ICI 182780, ICI182780
      References
      ReferencesWakeling, A. E., et al. 1991. Cancer Res. 51, 3867.
      Dauvois, S., et al. 1993. J. Cell. Sci. 106, 1377.
      Howell, A., et al. 1995. The Lancet. 8941, 29.
      Robertson, J.F., et al. 2001. J. Steroid Biochem. Mol Biol. 79, 209.
      Product Information
      CAS number129453-61-8
      DeclarationSold with the permission of AstraZeneca UK. Limited for research purposes only.
      FormWhite powder
      Hill FormulaC₃₂H₄₇F₅O₃S
      Chemical formulaC₃₂H₄₇F₅O₃S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetER
      Secondary targetGPR30
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.31042.0001 04055977242515

      Documentation

      Estrogen Receptor Antagonist, ICI 182,780 - CAS 129453-61-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Wakeling, A. E., et al. 1991. Cancer Res. 51, 3867.
      Dauvois, S., et al. 1993. J. Cell. Sci. 106, 1377.
      Howell, A., et al. 1995. The Lancet. 8941, 29.
      Robertson, J.F., et al. 2001. J. Steroid Biochem. Mol Biol. 79, 209.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-August-2014 JSW
      SynonymsGPR30 Agonist, ICI 182,780, ICI 182780, ICI182780
      DescriptionA cell-permeable estradiol derivative that acts as an estrogen antagonist and down-regulates estrogen receptors without affecting estrogen receptor-mediated progesterone receptor expression. Hence, it lacks estrogen agonist activity. Shown to be more effective than tamoxifen in reducing estrogen receptors in breast tumor cells. Suppresses the growth of MCF-7 xenografts in mice for twice as long as tamoxifen and delays tumor growth.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number129453-61-8
      Chemical formulaC₃₂H₄₇F₅O₃S
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWakeling, A. E., et al. 1991. Cancer Res. 51, 3867.
      Dauvois, S., et al. 1993. J. Cell. Sci. 106, 1377.
      Howell, A., et al. 1995. The Lancet. 8941, 29.
      Robertson, J.F., et al. 2001. J. Steroid Biochem. Mol Biol. 79, 209.