Millipore Sigma Vibrant Logo

530151 ATGL Inhibitor, Atglistatin - CAS 1469924-27-3 - Calbiochem

A cell-permeable, selective inhibitor of adipose triglyceride lipase activity (IC₅₀ = 700 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(4ʹ-(Dimethylamino)biphenyl-3-yl)-1,1-dimethylurea, Adipose Triglyceride Lipase Inhibitor

Primary Target: ATGL
View Products on Sigmaaldrich.com
530151
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1469924-27-3C₁₇H₂₁N₃O

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
5.30151.0001
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 10 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable biphenyldimethyl urea compound that inhibits adipose triglyceride lipase (ATGL) activity (IC50 = 700 nM; [Substrate] = [Triolein] = 165 µM) in a substrate-competitive (Ki = 355 nM) and highly selective manner. Shown to effectively suppress FA/glycerol productions from adipocytes (ICmax = 50 to 100 µM in 3T3-L1-differentiated adipocytes or primary murine WAT cultures) in vitro and in blood of mice in vivo via either oral or intraperitoneal administration (EDmax = 200 µmol/kg) with no significant cytotoxicity up to 50 µM in AML-12 murine hepatocyte cultures. Although TG accumulation in cardiac muscle causes cardiomyopathy, significant Atglistatin level is only seen in liver, white & brown adipose tissues in wt mice 8 h post single 200 µmol/kg oral dosage.



      Produced under the license of University of Graz/Graz University of Technology
      Catalogue Number530151
      Brand Family Calbiochem®
      Synonyms3-(4ʹ-(Dimethylamino)biphenyl-3-yl)-1,1-dimethylurea, Adipose Triglyceride Lipase Inhibitor
      References
      ReferencesMayer, N., et al. 2013. Nat. Chem. Biol. 9, 785.
      Product Information
      CAS number1469924-27-3
      FormBeige powder
      Hill FormulaC₁₇H₂₁N₃O
      Chemical formulaC₁₇H₂₁N₃O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetATGL
      Primary Target IC<sub>50</sub>700 nM
      Primary Target K<sub>i</sub>355 nM)
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.30151.0001 04055977241228

      Documentation

      ATGL Inhibitor, Atglistatin - CAS 1469924-27-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Mayer, N., et al. 2013. Nat. Chem. Biol. 9, 785.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2014 JSW
      Synonyms3-(4ʹ-(Dimethylamino)biphenyl-3-yl)-1,1-dimethylurea, Adipose Triglyceride Lipase Inhibitor
      DescriptionA cell-permeable biphenyldimethyl urea compound that inhibits adipose triglyceride lipase (ATGL) activity (IC50 = 700 nM; [Substrate] = [Triolein] = 165 µM) in a substrate-competitive (Ki = 355 nM) and highly selective manner, exhibiting little potency against hormone-sensitive lipase (HSL), monoglyceride lipase (MGL), pancreatic lipase, lipoprotein lipase, or lysophospholipases PNPLA6/7 even at concentrations as high as 100 µM. Shown to effectively suppress FA/glycerol productions from adipocytes (ICmax in vitro and in blood of mice in vivo via either oral or intraperitoneal administration (EDmax50 µM in AML-12 murine hepatocyte cultures. Although ATGL deficiency causes cardiomyopathy in human and ATGL-ko animals due to severe Triacylglycerol (TG) accumulation in cardiac muscle, significant Atglistatin level (>0.2 nmol/g tissue) is only seen in liver, white & brown adipose tissues, and detectable TG accumulation is only observed in liver tissue in wt mice 8 h post single 200 µmol/kg oral dosage.
      FormBeige powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1469924-27-3
      Chemical formulaC₁₇H₂₁N₃O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesMayer, N., et al. 2013. Nat. Chem. Biol. 9, 785.