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528180 Plasminogen, Glu-Type, Human Plasma

Plasminogen, Glu-Type, Human Plasma MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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528180
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Overview

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      		 Plastic ampoule 1 mg
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      Description
      OverviewNative Glu-type plasminogen from human plasma. Plasminogen is a single chain glycoprotein found in normal plasma at ~12 mg per deciliter, and is the inactive precursor of the serine protease plasmin.
      Catalogue Number528180
      Brand Family Calbiochem®
      References
      ReferencesCollen, D. 1986. In Blood Coagulation (Zwaal, R.E.A., and Hemker, H.C. eds.) Elsevier, N.Y. p. 243.
      Barlow, G.H., et al. 1984. Biochemistry 23, 2384.
      Wohl, R.C., et al. 1982. Thromb. Res. 27, 523.
      Castellino, F.J., et al. 1981. Methods Enzymol. 80, 365.
      Robbins, K.C. 1976. Methods Enzymol. 45, 257.
      Product Information
      FormLiquid
      FormulationIn 100 mM NaCl, 50 mM Tris-HCl, pH 7.5.
      Quality LevelMQ100
      Applications
      Biological Information
      PuritySingle band by SDS-PAGE
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Physicochemical Information
      ContaminantsPlasmin activity: none detected
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      528180-1MG 04055977196450

      Documentation

      Plasminogen, Glu-Type, Human Plasma SDS

      Title

      Safety Data Sheet (SDS) 

      Plasminogen, Glu-Type, Human Plasma Certificates of Analysis

      TitleLot Number
      528180

      References

      Reference overview
      Collen, D. 1986. In Blood Coagulation (Zwaal, R.E.A., and Hemker, H.C. eds.) Elsevier, N.Y. p. 243.
      Barlow, G.H., et al. 1984. Biochemistry 23, 2384.
      Wohl, R.C., et al. 1982. Thromb. Res. 27, 523.
      Castellino, F.J., et al. 1981. Methods Enzymol. 80, 365.
      Robbins, K.C. 1976. Methods Enzymol. 45, 257.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-May-2008 RFH
      DescriptionNative Glu-type plasminogen from human plasma. Plasminogen is a single chain glycoprotein zymogen, which is synthesized in the liver and circulates in plasma at a concentration of approximately 2.4 µM. The plasminogen molecule contains 790 amino acids, 24 disulfide bridges, no free sulfhydryls, and 5 regions of internal sequence homology, known as kringles, between Lys77 and Arg560. These kringle regions are homologous to the kringle domains in t-PA, u-PA, and prothrombin. Native Glu-plasminogen is readily converted to Lys77-plasminogen by plasmin hydrolysis of the Lys76-Lys77 peptide bond. The plasminogen is converted to plasmin by cleavage at Arg540-Val561 by urokinase, streptokinase, or tissue plasminogen activator.
      FormLiquid
      FormulationIn 100 mM NaCl, 50 mM Tris-HCl, pH 7.5.
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      PuritySingle band by SDS-PAGE
      ContaminantsPlasmin activity: none detected
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      Merck USA index14, 7521
      ReferencesCollen, D. 1986. In Blood Coagulation (Zwaal, R.E.A., and Hemker, H.C. eds.) Elsevier, N.Y. p. 243.
      Barlow, G.H., et al. 1984. Biochemistry 23, 2384.
      Wohl, R.C., et al. 1982. Thromb. Res. 27, 523.
      Castellino, F.J., et al. 1981. Methods Enzymol. 80, 365.
      Robbins, K.C. 1976. Methods Enzymol. 45, 257.