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506600 Pamidronate, Disodium Salt - CAS 109552-15-0 - Calbiochem

A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate

Primary Target: Inhibitor of bone resorption
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506600
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
109552-15-0C₃H₉NO₇P₂·2Na·5H₂O

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      Description
      OverviewA potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget’s disease, hypercalcaemia of malignancy, osteolytic bone metastasis, steroid-induced osteoporosis, and idiopathic osteoporosis. Inhibits breast cancer cell growth by inducing cell death in vitro. Provided in hydrated form, contains five molecules of water.
      Catalogue Number506600
      Brand Family Calbiochem®
      Synonyms3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate
      References
      ReferencesFromigue, O., et al. 2000. J. Bone Miner. Res. 15, 2211.
      Fitton, A., and McTravish, D. 1991. Drugs 41, 289.
      Product Information
      CAS number109552-15-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃H₉NO₇P₂·2Na·5H₂O
      Chemical formulaC₃H₉NO₇P₂·2Na·5H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInhibitor of bone resorption
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSSZ6522666
      Safety Information
      R PhraseR: 20/21/22-61

      Harmful by inhalation, in contact with skin and if swallowed.
      May cause harm to the unborn child.
      S PhraseS: 36-45

      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      506600-10MG 04055977272482

      Documentation

      Pamidronate, Disodium Salt - CAS 109552-15-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Pamidronate, Disodium Salt - CAS 109552-15-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      506600

      References

      Reference overview
      Fromigue, O., et al. 2000. J. Bone Miner. Res. 15, 2211.
      Fitton, A., and McTravish, D. 1991. Drugs 41, 289.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-May-2008 RFH
      Synonyms3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate
      DescriptionA calcium metabolism regulator. A potent and specific inhibitor of bone resorption at doses devoid of any significant detrimental effect on bone growth and mineralization. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget's disease, hypercalcemia of malignancy, osteolytic bone metastasis, and steroid-induced cell death in vitro. Provided in a hydrated form containing five molecules of water.
      FormWhite solid
      CAS number109552-15-0
      RTECSSZ6522666
      Chemical formulaC₃H₉NO₇P₂·2Na·5H₂O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 7003
      ReferencesFromigue, O., et al. 2000. J. Bone Miner. Res. 15, 2211.
      Fitton, A., and McTravish, D. 1991. Drugs 41, 289.