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475879 Monastrol - CAS 254753-54-3 - Calbiochem

A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor.

Monastrol - CAS 254753-54-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I

Primary Target: Mitotic kinesin Eg5
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475879
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Overview

Key Spec Table

CAS #Empirical Formula
254753-54-3C₁₄H₁₆N₂O₃S

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475879-1MG
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      475879-5MG
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          Description
          OverviewA potent, cell-permeable, non-tubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC50 = 14 µM).
          Catalogue Number475879
          Brand Family Calbiochem®
          Synonyms4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I
          References
          ReferencesKapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
          Mayer, T.U., et al. 1999. Science 286, 971.
          Product Information
          CAS number254753-54-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₄H₁₆N₂O₃S
          Chemical formulaC₁₄H₁₆N₂O₃S
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Biological Information
          Primary TargetMitotic kinesin Eg5
          Primary Target IC<sub>50</sub>14 µM against mitotic kinesin Eg5
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Global Trade Item Number
          Catalogue Number GTIN
          475879-1MG 04055977203479
          475879-5MG 04055977203486