475867 Sigma-AldrichMn-cpx 3 - Calbiochem
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Overview
Key Spec Table
| Empirical Formula |
|---|
| C₃₀H₂₀Cl₂MnO₆ |
| Description | |
|---|---|
| Overview | This product has been discontinued. A cell-permeable manganese complex of 7-hydroxyflavone that acts as a superoxide dismustase (SOD) mimetic and a neuroprotective agent against radical-induced damages. Shown to prevent the reduction of NBT by O2– • (IC50 = 1.18 µM) and exhibit ~10 times higher potency than Trolox (Cat. No. 648471) in inhibiting lipid peroxidation (IC50 = 6.15 µM) in vitro. Suppresses MAP (methamphetamine)-induced brain hypermotility in mice and shows protective effects against learning and memory impairment in a murine ischemic model in vivo. |
| Catalogue Number | 475867 |
| Brand Family | Calbiochem® |
| References | |
|---|---|
| References | Vajragupta, O., et al. 2003. Bioorg. Med. Chem. 11, 2329. |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | Pale yellow solid |
| Hill Formula | C₃₀H₂₀Cl₂MnO₆ |
| Chemical formula | C₃₀H₂₀Cl₂MnO₆ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Superoxide dismustase (SOD) mimetic |
| Primary Target IC<sub>50</sub> | 1.18 µM in preventing the reduction of NBT by O2- • in vitro |
| Purity | ≥98% by elemental analysis |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 475867 | 0 |