444158 Sigma-AldrichMDMX Inhibitor, NSC207895 - Calbiochem
The MDMX Inhibitor, NSC207895 controls the biological activity of MDMX. This small molecule/inhibitor is primarily used for Cancer applications.
More>> The MDMX Inhibitor, NSC207895 controls the biological activity of MDMX. This small molecule/inhibitor is primarily used for Cancer applications. Less<<MDMX Inhibitor, NSC207895 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 7-(4-Methylpiperazin-1-yl)-4-nitro-2,1,3-benzoxadiazole-1-oxide, 7-(4-Methylpiperazin-1-yl)-4-nitro-1-oxido-2,1,3-benzoxadiazol-1-ium, XI-006
Recommended Products
Overview
| Replacement Information |
|---|
Key Spec Table
| Empirical Formula |
|---|
| C₁₁H₁₃N₅O₄ |
| Description | |
|---|---|
| Overview | This product has been discontinued. A cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation. A great complement to MDM2 antagonist Nutlin-3 (Cat. Nos. 444143 & 444151) in growth inhibition and apoptosis induction of cancer cells that are more sensitive to MDMX than MDM2 inhibition. |
| Catalogue Number | 444158 |
| Brand Family | Calbiochem® |
| Synonyms | 7-(4-Methylpiperazin-1-yl)-4-nitro-2,1,3-benzoxadiazole-1-oxide, 7-(4-Methylpiperazin-1-yl)-4-nitro-1-oxido-2,1,3-benzoxadiazol-1-ium, XI-006 |
| References | |
|---|---|
| References | Wang, H., et al. 2011. Mol. Cancer Ther. 7, 611. Berkson, R.G., et al. 2005. Int. J. Cancer 115, 701. |
| Product Information | |
|---|---|
| Form | Dark red solid |
| Hill Formula | C₁₁H₁₃N₅O₄ |
| Chemical formula | C₁₁H₁₃N₅O₄ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Purity | ≥98% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 444158 | 0 |
Documentation
MDMX Inhibitor, NSC207895 - Calbiochem SDS
| Title |
|---|
MDMX Inhibitor, NSC207895 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 444158 |
References
| Reference overview |
|---|
| Wang, H., et al. 2011. Mol. Cancer Ther. 7, 611. Berkson, R.G., et al. 2005. Int. J. Cancer 115, 701. |
| Data Sheet | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|