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437720 Lipoxin A₄ - CAS 89663-86-5 - Calbiochem

Lipoxin A₄, CAS 89663-86-5, is a potent inhibitor of cytotoxic activity of human natural killer cells. Shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides.

Lipoxin A₄ - CAS 89663-86-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: LXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7-trans-9-trans-11-cis-13-trans-tetraenoic Acid

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437720
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
89663-86-5C₂₀H₃₂O₅

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437720-25UG
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      		 Glass bottle 25 μg
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      Description
      OverviewPotent inhibitor of cytotoxic activity of human natural killer cells; shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides. Involved in contractile responses and acts as a potent activator of human protein kinase C. Stimulates rapid lipid remodeling and pertussis-sensitive release of arachidonic acid in polymorphonuclear leukocytes. Stimulates MAP kinases via activation of G protein-coupled receptors.
      Caution! Product contains volatile liquid. Keep product cold at all times.
      Catalogue Number437720
      Brand Family Calbiochem®
      SynonymsLXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7-trans-9-trans-11-cis-13-trans-tetraenoic Acid
      References
      ReferencesMcMahon, B., et al. 2000. J. Biol. Chem. 275, 27566.
      Soyombo, O., et al. 1994. Allergy 49, 230.
      Flore, S., et al. 1992. J. Biol. Chem. 267, 16168.
      Badr, K.F., et al. 1989. Proc. Natl. Acad. Sci. USA 86, 3438.
      Product Information
      CAS number89663-86-5
      ATP CompetitiveN
      FormLiquid
      FormulationIn Ethanol.
      Hill FormulaC₂₀H₃₂O₅
      Chemical formulaC₂₀H₃₂O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPotent inhibitor of cytotoxic activity of human natural killer cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 11-36/37/38

      Highly flammable.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 16-26-36-7

      Keep away from sources of ignition - No Smoking.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Keep container tightly closed.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Flammable
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      437720-25UG 04055977186888

      Documentation

      Lipoxin A₄ - CAS 89663-86-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Lipoxin A₄ - CAS 89663-86-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      437720

      References

      Reference overview
      McMahon, B., et al. 2000. J. Biol. Chem. 275, 27566.
      Soyombo, O., et al. 1994. Allergy 49, 230.
      Flore, S., et al. 1992. J. Biol. Chem. 267, 16168.
      Badr, K.F., et al. 1989. Proc. Natl. Acad. Sci. USA 86, 3438.

      Brochure

      Title
      Bioactive Lipids Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2008 RFH
      SynonymsLXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7-trans-9-trans-11-cis-13-trans-tetraenoic Acid
      DescriptionPotent inhibitor of cytotoxic activity of human natural killer cells. Shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides. Involved in contractile responses and acts as a potent enhancer of human protein kinase C. Stimulates the rapid lipid remodeling and pertussis-sensitive release of arachidonic acid in polymorphonuclear leukocytes.
      FormLiquid
      FormulationIn Ethanol.
      CAS number89663-86-5
      Chemical formulaC₂₀H₃₂O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityEthanol
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Flammable
      ReferencesMcMahon, B., et al. 2000. J. Biol. Chem. 275, 27566.
      Soyombo, O., et al. 1994. Allergy 49, 230.
      Flore, S., et al. 1992. J. Biol. Chem. 267, 16168.
      Badr, K.F., et al. 1989. Proc. Natl. Acad. Sci. USA 86, 3438.