420361 Sigma-AldrichKMO Inhibitor II, JM6 - Calbiochem
The KMO Inhibitor II, JM6 controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.
More>> The KMO Inhibitor II, JM6 controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications. Less<<KMO Inhibitor II, JM6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Kynurenine-3-Monooxygenase Inhibitor II, JM6, Kynurenine-3-Hydroxylase Inhibitor II, JM6, 2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole, KMO Inhibitor I, Ro 61-8048 Prodrug
Recommended Products
Overview
| Replacement Information |
|---|
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 420361-10MG |
|
Glass bottle | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | An orally bioavailable in-vivo prodrug of KMO Inhibitor I, Ro 61-8048 (Cat. No. 420360) that is shown to be metabolically unstable and slowly release Ro 61-8048 in blood and act as a neuroprotectant. Blocks KMO peripherally (IC50 = 4 µM) and sustainingly elevates kynurenic acid (KYNA) brain levels, an antagonist of excitatory amino acid receptors. Shown to prevent synaptic loss and behavioral deficits in AD and HD mouse model and increase the survival. |
| Catalogue Number | 420361 |
| Brand Family | Calbiochem® |
| Synonyms | Kynurenine-3-Monooxygenase Inhibitor II, JM6, Kynurenine-3-Hydroxylase Inhibitor II, JM6, 2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole, KMO Inhibitor I, Ro 61-8048 Prodrug |
| References | |
|---|---|
| References | Campesan, S., et al. 2011. Chem. Biol. 21, 961. Zwilling, D., et al. 2011. Cell 145, 863. |
| Product Information | |
|---|---|
| Form | Yellow powder |
| Hill Formula | C₂₃H₂₆N₄O₆S₂ |
| Chemical formula | C₂₃H₂₆N₄O₆S₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Purity | ≥97% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 420361-10MG | 04055977187564 |
Documentation
KMO Inhibitor II, JM6 - Calbiochem SDS
| Title |
|---|
KMO Inhibitor II, JM6 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 420361 |
References
| Reference overview |
|---|
| Campesan, S., et al. 2011. Chem. Biol. 21, 961. Zwilling, D., et al. 2011. Cell 145, 863. |
| Data Sheet | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|