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407623 Interleukin-2, Human, Recombinant, E. coli

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: rhIL-2

407623
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      Recombinant, human interleukin-2 expressed in E. coli. Has a variety of immunological functions. IL-2 is secreted by activated T cells. Acts as an autocrine agent to promote proliferation and maturation of activated T cells. Human IL-2 is active in murine cell lines. Exhibits about 60% amino acid homology with murine IL-2. Inhibits dexamethasone-induced apoptosis in T lymphocytes. Induces nitric oxide synthase.
      Catalogue Number407623
      Brand Family Calbiochem®
      SynonymsrhIL-2
      References
      ReferencesMigliorati, G., et al. 1994. Pharmacol. Res. 30, 43.
      Nakamura, Y., et al. 1994. Cancer Res. 54, 5757.
      Karanth, S., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3383.
      Maeda, A., et al. 1983. Biochem. Biophys. Res. Commun. 115, 1040.
      Taniguchi, T., et al. 1983. Nature 302, 305.
      Product Information
      FormLyophilized
      FormulationCarrier-free
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀= 80-500 pg/ml as measured in a cell proliferation assay with an IL-2-dependent murine cytotoxic T cell line
      Purity≥95% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤100 pg/µg IL-2
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSNM9742000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407623 0

      Documentation

      Interleukin-2, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      Interleukin-2, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      407623

      References

      Reference overview
      Migliorati, G., et al. 1994. Pharmacol. Res. 30, 43.
      Nakamura, Y., et al. 1994. Cancer Res. 54, 5757.
      Karanth, S., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3383.
      Maeda, A., et al. 1983. Biochem. Biophys. Res. Commun. 115, 1040.
      Taniguchi, T., et al. 1983. Nature 302, 305.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2008 RFH
      SynonymsrhIL-2
      DescriptionRecombinant, human interleukin-2 expressed in E. coli. Has a variety of immunological functions. Acts as an autocrine agent to promote proliferation and maturation of activated T cells. A comparison of the amino acid sequences of human and murine IL-2 shows ~60% sequence similarity. Inhibits dexamethasone-induced apoptosis in T-lymphocytes. Induces nitric oxide synthase. Human IL-2 is active in murine cell lines. Validated for use in cell culture and bioassays.
      FormLyophilized
      FormulationCarrier-free
      RTECSNM9742000
      Purity≥95% by SDS-PAGE
      ContaminantsEndotoxin: ≤100 pg/µg IL-2
      Biological activityED₅₀= 80-500 pg/ml as measured in a cell proliferation assay with an IL-2-dependent murine cytotoxic T cell line
      SolubilityReconstitute to a concentration of 0.1-1 mg/ml with sterile 100 mM acetic acid. Further dilute in buffer or medium containing ≥0.1% BSA.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      Merck USA index14, 4994
      ReferencesMigliorati, G., et al. 1994. Pharmacol. Res. 30, 43.
      Nakamura, Y., et al. 1994. Cancer Res. 54, 5757.
      Karanth, S., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3383.
      Maeda, A., et al. 1983. Biochem. Biophys. Res. Commun. 115, 1040.
      Taniguchi, T., et al. 1983. Nature 302, 305.