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407245 Insulin-Like Growth Factor-II, Human, Recombinant, E. coli

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: rhIGF-II

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407245
  
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      Overview

      Replacement Information

      Key Spec Table

      Purity
      ≥97% by SDS-PAGE
      Description
      OverviewRecombinant, human insulin-like growth factor-II expressed in E. coli. Its actions are similar to IGF-1 (Cat. No. 407240). Plays an important role in fetal development. Stimulates muscle and bone cell proliferation and differentiation.
      Catalogue Number407245
      Brand Family Calbiochem®
      SynonymsrhIGF-II
      References
      ReferencesFeldser, D., et al. 1999. Cancer Res. 59, 3915.
      Hill, P.A., et al. 1995. Endocrinology 136, 124.
      Nielson, F.C., et al. 1995. Nature 377, 358.
      LeRoith, D., and Roberts, C.R., Jr. 1993. Ann. N.Y. Acad. Sci. 692, 1.
      Lowe, W.L. 1991. In Insulin-Like Growth Factors: Molecular and Cellular Aspects (LeRoith, D., Ed.) CRC Press Inc., Boca Raton p. 49.
      Rotwein, P. 1991. Growth Factors 5, 3.
      Product Information
      CAS number67763-97-7
      FormLyophilized
      FormulationLyophilized from sterile-filtered acetic acid.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀ = 5-10 ng/ml
      Purity≥97% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: <1 EU/µg IGF-II
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSNM8906000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407245 0

      Documentation

      Insulin-Like Growth Factor-II, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      Insulin-Like Growth Factor-II, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      407245

      References

      Reference overview
      Feldser, D., et al. 1999. Cancer Res. 59, 3915.
      Hill, P.A., et al. 1995. Endocrinology 136, 124.
      Nielson, F.C., et al. 1995. Nature 377, 358.
      LeRoith, D., and Roberts, C.R., Jr. 1993. Ann. N.Y. Acad. Sci. 692, 1.
      Lowe, W.L. 1991. In Insulin-Like Growth Factors: Molecular and Cellular Aspects (LeRoith, D., Ed.) CRC Press Inc., Boca Raton p. 49.
      Rotwein, P. 1991. Growth Factors 5, 3.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2008 RFH
      SynonymsrhIGF-II
      DescriptionRecombinant, human insulin-like growth factor-II expressed in E. coli. A growth-promoting peptide that is structurally related to insulin. IGF-II shares about 76% sequence identity with IGF-I and ~50% with pro-insulin. Its actions are similar to IGF-I (Cat. No. 407240). IGF-II is a nonglycosylated, single chain peptide of 67 amino acids. Plays an important role in fetal development. Stimulates muscle and bone cell proliferation and differentiation.
      FormLyophilized
      FormulationLyophilized from sterile-filtered acetic acid.
      CAS number67763-97-7
      RTECSNM8906000
      Purity≥97% by SDS-PAGE
      ContaminantsEndotoxin: <1 EU/µg IGF-II
      Biological activityED₅₀ = 5-10 ng/ml
      SolubilityReconstitute to a concentration of ≥10 µg/ml with sterile PBS containing ≥0.1% HSA or BSA. Avoid using buffers near the isoelectric point (6.5).
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Toxicity Standard Handling
      Merck USA index14, 4986
      ReferencesFeldser, D., et al. 1999. Cancer Res. 59, 3915.
      Hill, P.A., et al. 1995. Endocrinology 136, 124.
      Nielson, F.C., et al. 1995. Nature 377, 358.
      LeRoith, D., and Roberts, C.R., Jr. 1993. Ann. N.Y. Acad. Sci. 692, 1.
      Lowe, W.L. 1991. In Insulin-Like Growth Factors: Molecular and Cellular Aspects (LeRoith, D., Ed.) CRC Press Inc., Boca Raton p. 49.
      Rotwein, P. 1991. Growth Factors 5, 3.

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      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors