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402086 Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Gsk-3β
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402086
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      331467-03-9C₁₆H₁₀IN₃O₂
      Description
      Overview

      This product has been discontinued.



      A highly potent cell-permeable and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 9 nM). Also inhibits Cdk1 (IC50 = 25 nM) and Cdk5 (IC50 = 20 nM) activities. Acts by binding to the ATP-binding pocket of these enzymes.
      Catalogue Number402086
      Brand Family Calbiochem®
      References
      ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
      Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.
      Product Information
      CAS number331467-03-9
      ATP CompetitiveY
      FormDark red solid
      Hill FormulaC₁₆H₁₀IN₃O₂
      Chemical formulaC₁₆H₁₀IN₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGsk-3β
      Primary Target IC<sub>50</sub>9 nM against GSK-3β
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      402086 0

      Documentation

      Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Leclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
      Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.

      Brochure

      Title
      Alzheimer's Disease Brochure & Technical Guide
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      DescriptionA highly potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50 = 9 nM). Reported to inhibit GSK-3β phosphorylation of human tau protein in vitro (IC50 ~100 nM) and in cells (effective concentration = 20 µM). Also inhibits CDK1 (IC50 = 25 nM) and CDK5 (IC50 = 20 nM). Shown to inhibit phosphorylation of DARPP-32 by CDK5 in brain sections enriched for DARPP-32. Inhibition is competitive with respect to ATP.
      FormDark red solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number331467-03-9
      Chemical formulaC₁₆H₁₀IN₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
      Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.