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373400 Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem

The Hh/Gli Antagonist, GANT58, also referenced under CAS 64048-12-0, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503

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373400
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
64048-12-0C₂₄H₁₆N₄S

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      Description
      OverviewA cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells). Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding. Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo.
      Catalogue Number373400
      Brand Family Calbiochem®
      Synonyms4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503
      References
      ReferencesLauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.
      Product Information
      CAS number64048-12-0
      FormYellow solid
      Hill FormulaC₂₄H₁₆N₄S
      Chemical formulaC₂₄H₁₆N₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      373400-5MG 04055977191110

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      373400

      References

      Reference overview
      Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      Synonyms4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503
      DescriptionA cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC50 ~5 µM in SAG-stimulated Shh-L2 cells). Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding. Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number64048-12-0
      Chemical formulaC₂₄H₁₆N₄S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesLauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.