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361524 GSK-3β, His•Tag®, Human, Recombinant, E. coli

GSK-3β, His-Tag®, Human, Recombinant, E. coli, is a dual specificity kinase that plays important roles in insulin- and Wnt-mediated signaling. It is inactivated by phosphorylation at Ser9.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GSK-3β, Tau Protein Kinase I, TPK I

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361524
  
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      Overview

      Description
      OverviewRecombinant, human GSK-3β fused at the N-terminus to a His•Tag® sequence and expressed in E. coli. A dual specificity kinase that plays important roles in insulin- and Wnt-mediated cellular signalings. In AD (Alzheimer’s disease), GSK3β has a major role in microtubule stability by its ability to phosphorylate the microtubule associated protein tau. Its known substrates include glycogen synthase, p90rsk, Tau, c-Jun, and CREB. MW: 53,000-56,000.
      Catalogue Number361524
      Brand Family Calbiochem®
      SynonymsGSK-3β, Tau Protein Kinase I, TPK I
      References
      ReferencesHarwood, A., and Braga, V.M. 2003. Nat. Cell Biol. 5, 275.
      Bhat, R.V., and Budd, S.L. 2002. Neurosignals 11, 251.
      Product Information
      FormSolid
      FormulationLyophilized from 0.1 M NH₄CO₃.
      Quality LevelMQ100
      Applications
      ApplicationGSK-3β, His-Tag®, Human, Recombinant, E. coli, is a dual specificity kinase that plays important roles in insulin- and Wnt-mediated signaling. It is inactivated by phosphorylation at Ser9.
      Biological Information
      Biological activity1 µg GSK-3β maximally phosphorylates 100 ng Tau protein in 30 min in an in vitro kinase assay at 30°C, pH 7.5
      Purity≥90% by SDS-PAGE
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Global Trade Item Number
      Catalogue Number GTIN
      361524 0