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345834 Genistein, Soybean - CAS 446-72-0 - Calbiochem

A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC₅₀ = 2.6 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4ʹ,5,7-Trihydroxyisoflavone

Primary Target: EGFR kinase
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345834
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Overview

Key Spec Table

CAS #Empirical Formula
446-72-0C₁₅H₁₀O₅

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345834-20MG
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      345834-50MG
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          Description
          OverviewA cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Has only a trivial effect on the activity of PKA and PKC (IC50 > 350 µM). Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro.
          Catalogue Number345834
          Brand Family Calbiochem®
          Synonyms4ʹ,5,7-Trihydroxyisoflavone
          References
          ReferencesConstantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
          Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
          Wei, H., et al. 1995. Carcinogenesis 17, 73.
          Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
          Migita, K., et al. 1994. J. Immunol. 153, 3457.
          Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
          Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
          Hill, T.D., et al. 1990. Science 248, 1660.
          Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
          Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
          Product Information
          CAS number446-72-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₅H₁₀O₅
          Chemical formulaC₁₅H₁₀O₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Biological Information
          Primary TargetEGFR kinase
          Primary Target IC<sub>50</sub>2.6 µM against autophosphorylation of epidermal growth factor receptor kinase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Safety Information according to GHS
          RTECSNR2392000
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Global Trade Item Number
          Catalogue Number GTIN
          345834-20MG 04055977214376
          345834-50MG 04055977214383