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344220 Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ - Calbiochem

The Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ controls the biological activity of Formyl Peptide Receptor-Like 1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: H₂N-WRWWWW-CONH₂, FPRL1 Antagonist, WRW⁴

Primary Target: Formyl Peptide Receptor-Like 1 (FPRL1)
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344220
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₆₁H₆₅N₁₅O₆

Pricing & Availability

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344220-5MG
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      		 Plastic ampoule 5 mg
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      Description
      OverviewA Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca2+]i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages.
      Catalogue Number344220
      Brand Family Calbiochem®
      SynonymsH₂N-WRWWWW-CONH₂, FPRL1 Antagonist, WRW⁴
      References
      ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₁H₆₅N₁₅O₆
      Chemical formulaC₆₁H₆₅N₁₅O₆
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFormyl Peptide Receptor-Like 1 (FPRL1)
      Primary Target IC<sub>50</sub>230 nM for FPRL1 Agonist
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      344220-5MG 04055977215335

      Documentation

      Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ - Calbiochem Certificates of Analysis

      TitleLot Number
      344220

      References

      Reference overview
      Bae, Y.S., et al. 2004. J. Immunol. 173, 607.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-June-2008 RFH
      SynonymsH₂N-WRWWWW-CONH₂, FPRL1 Antagonist, WRW⁴
      DescriptionA Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks ligand-mediated [Ca2+]i increase, ERK activation, and chemotactic migration of FPRL1-expressing RBL-2H3 cells at a concentration of 10 µM. Also inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₆₁H₆₅N₁₅O₆
      Peptide SequenceH-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.