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344096 InSolution™ Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem

A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (±)-(3Rʹ,5Sʹ,6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3,5-dihydroxy-6-heptenoate, sodium

Primary Target: HMG-CoA reductase
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344096
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Overview

Key Spec Table

CAS #Empirical Formula
93957-55-2C₂₄H₂₅FNNaO₄

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344096-10MG
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      Description
      OverviewA synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. 438185), Mevastatin (Cat. No. 474700), and Simvastatin (Cat. No. 567020), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealkylation and β-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity.
      Catalogue Number344096
      Brand Family Calbiochem®
      Synonyms(±)-(3Rʹ,5Sʹ,6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3,5-dihydroxy-6-heptenoate, sodium
      References
      ReferencesYamamoto, A., et al. 2001. J. Pharm. Pharmacol. 53, 227.
      Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol. 52, 145.
      Ikeda, U., et al. 2000. Hypertension 36, 325.
      Levy, R.I., et al. 1993. Circulation 87 (4 Suppl.), III45.
      Tse, F.L.S. et al. 1992. J. Clin. Pharmacol. 32, 630.
      Yuan, J., et al. 1991. Atherosclerosis 87, 147.
      Product Information
      CAS number93957-55-2
      FormLiquid
      FormulationA 10 mM (10 mg/2.13 ml) solution of Fluvastatin, Sodium Salt (344095) in H₂O.
      Hill FormulaC₂₄H₂₅FNNaO₄
      Chemical formulaC₂₄H₂₅FNNaO₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetHMG-CoA reductase
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      344096-10MG 04055977215199