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341598 Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem

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341598
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₁H₁₄N₂Na₂O₉S₂
      Description
      Overview

      This product has been discontinued.



      A small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC50 = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC50 = 24.0 ±6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC50 = 20.3 µM ±5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ±2 (FGF-2 + NSC37203).
      Catalogue Number341598
      Brand Family Calbiochem®
      References
      ReferencesColombo, G., et al. 2010. J. Biol. Chem. 285, 8733.
      Product Information
      FormBrown solid
      Hill FormulaC₂₁H₁₄N₂Na₂O₉S₂
      Chemical formulaC₂₁H₁₄N₂Na₂O₉S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity>95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      341598 0

      Documentation

      Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem Certificates of Analysis

      TitleLot Number
      341598

      References

      Reference overview
      Colombo, G., et al. 2010. J. Biol. Chem. 285, 8733.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-December-2010 RFH
      DescriptionA small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC50 = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC50 = 24.0 ± 6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC50 = 20.3 µM ± 5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ± 2 (FGF-2 + NSC37203).
      FormBrown solid
      Chemical formulaC₂₁H₁₄N₂Na₂O₉S₂
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesColombo, G., et al. 2010. J. Biol. Chem. 285, 8733.