Millipore Sigma Vibrant Logo

328500 ERO1 Inhibitor I, Erodoxin - CAS 181995-71-1 - Calbiochem

The ERO1 Inhibitor I, Erodoxin controls the biological activity of ERO1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-Bromo-5-methoxy-2,4-dinitrobenzene, Endoplasmic Reticulum Oxidase 1 Inhibitor

View Products on Sigmaaldrich.com
328500
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
181995-71-1C₇H₅BrN₂O₅

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
328500-25MG
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 25 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1α (IC50 = 400 µM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells.
      Catalogue Number328500
      Brand Family Calbiochem®
      Synonyms1-Bromo-5-methoxy-2,4-dinitrobenzene, Endoplasmic Reticulum Oxidase 1 Inhibitor
      References
      ReferencesCostanzo, M., et al. 2010. Science 327, 425.
      Blais, J.D., et al. 2010. J. Biol. Chem. 285, 20993.
      Product Information
      CAS number181995-71-1
      FormYellow solid
      Hill FormulaC₇H₅BrN₂O₅
      Chemical formulaC₇H₅BrN₂O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      328500-25MG 04055977195637

      Documentation

      ERO1 Inhibitor I, Erodoxin - CAS 181995-71-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      ERO1 Inhibitor I, Erodoxin - CAS 181995-71-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      328500

      References

      Reference overview
      Costanzo, M., et al. 2010. Science 327, 425.
      Blais, J.D., et al. 2010. J. Biol. Chem. 285, 20993.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-July-2012 JSW
      Synonyms1-Bromo-5-methoxy-2,4-dinitrobenzene, Endoplasmic Reticulum Oxidase 1 Inhibitor
      DescriptionA cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1α (IC50 = 400 µM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number181995-71-1
      Chemical formulaC₇H₅BrN₂O₅
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml). Use only fresh DMSO
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesCostanzo, M., et al. 2010. Science 327, 425.
      Blais, J.D., et al. 2010. J. Biol. Chem. 285, 20993.