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328010 InSolution™ ERK Inhibitor II, FR180204 - Calbiochem

The InSolution™ ERK Inhibitor II, FR180204, also referenced under CAS 865362-74-9, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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328010
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₈H₁₃N₇
      Description
      OverviewA cell-permeable pyrazolopyridazinamine that acts as a potent, ATP-competitive inhibitor of ERK1 and ERK2 (IC50 = 510 nM and 330 nM; Ki = 310 nM and 140 nM, respectively). Exhibits ~20-fold greater selectivity over p38α (IC50 = 10 µM) and shows little activity towards IKKα, MEK1, MKK4, PDGFRα, PKCα, Src, and Syk even at concentrations as high as 30 µM. Shown to inhibit TGF-β−induced AP-1 activation in Mv1Lu epithelial cells (IC50 of 3.1 µM). ERK Inhibitor II, Negative Control (Cat. No. 328008) and the solid form of this compound (Cat. No. 328007) are also available..
      Catalogue Number328010
      Brand Family Calbiochem®
      References
      ReferencesOhori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.
      Product Information
      FormLiquid
      FormulationA 10 mM (500 µg/153 µl) solution of ERK Inhibitor II, FR180204 (Cat. No. 328007) in DMSO.
      Hill FormulaC₁₈H₁₃N₇
      Chemical formulaC₁₈H₁₃N₇
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      328010 0

      Documentation

      InSolution™ ERK Inhibitor II, FR180204 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ ERK Inhibitor II, FR180204 - Calbiochem Certificates of Analysis

      TitleLot Number
      328010

      References

      Reference overview
      Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-January-2012 RFH
      DescriptionA cell-permeable pyrazolopyridazinamine that acts as a potent, ATP-competitive inhibitor of ERK1 and ERK2 (IC50 = 510 nM and 330 nM; Ki = 310 nM and 140 nM, respectively). Exhibits ~20-fold greater selectivity over p38α (IC50 = 10 µM) and shows little activity towards IKKα, MEK1, MKK4, PDGFRα, PKCα, Src, and Syk even at concentrations as high as 30 µM. Shown to inhibit TGF-β−induced AP-1 activation in Mv1Lu epithelial cells (IC50 of 3.1 µM). ERK Inhibitor II, Negative Control is also available (Cat. No. 328008).
      FormLiquid
      FormulationA 10 mM (500 µg/153 µl) solution of ERK Inhibitor II, FR180204 (Cat. No. 328007) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₁₃N₇
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesOhori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.