324387 Sigma-AldrichDopamine Receptor Antagonist II, Thioridazine, HCl - CAS 130-61-0 - Calbiochem
The Dopamine Receptor Antagonist II, Thioridazine, HCl, also referenced under CAS 130-61-0, controls the biological activity of Dopamine Receptor. This small molecule/inhibitor is primarily used for Biochemicals applications.
More>> The Dopamine Receptor Antagonist II, Thioridazine, HCl, also referenced under CAS 130-61-0, controls the biological activity of Dopamine Receptor. This small molecule/inhibitor is primarily used for Biochemicals applications. Less<<Synonyms: 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)-10H-phenothiazine, HCl, 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine, HCl
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 130-61-0 | C₂₁H₂₆N₂S₂ •HCl |
| Description | |
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| Overview | This product has been discontinued. A phenothiazine class antipsychotic and dopamine receptor (DR) antagonist that is reported to exhibit CSCs- (cancer stem cells) differentiating (EC50 ≤9.4 µM for v1H9) and anti-leukemic activity, without affecting non-neoplastic H9 hESC, adult fibroblast-derived iPSC, or HSPCs (hematopoietic stem-progenitor cells). However, Thioridazine's high effective concentration (10 µM) against cancer cells suggests that other unidentified cellular targets/mechanisms in addition to DR antagonism may be also involved in its overall anti-CSC impact. Effectively augments AraC (Cat. No. 251010) in inhibiting primary AML in vitro colony formation (by 79%, 55%, and 100%, respectively, with 10 µM Thioridazine, 0.1 µM AraC, or a combination of both). |
| Catalogue Number | 324387 |
| Brand Family | Calbiochem® |
| Synonyms | 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)-10H-phenothiazine, HCl, 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine, HCl |
| References | |
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| References | Sachlos, E., et al. 2012. Cell 149, 1284. |
| Product Information | |
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| CAS number | 130-61-0 |
| Form | Off-white solid |
| Hill Formula | C₂₁H₂₆N₂S₂ •HCl |
| Chemical formula | C₂₁H₂₆N₂S₂ •HCl |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Purity | ≥98% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 324387 | 0 |
Documentation
Dopamine Receptor Antagonist II, Thioridazine, HCl - CAS 130-61-0 - Calbiochem SDS
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Dopamine Receptor Antagonist II, Thioridazine, HCl - CAS 130-61-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 324387 |
References
| Reference overview |
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| Sachlos, E., et al. 2012. Cell 149, 1284. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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