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292505 Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem

An esterase-sensitive and cell permeable, O²-acetoxymethylated diazeniumdiolate that acts as an intracellular nitric oxide (NO) donor (1.83 mol of NO/mol).

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292505
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Overview

Key Spec Table

CAS #Empirical Formula
213768-16-2C₇H₁₅N₃O₄

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292505-1MG
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      Description
      OverviewAn esterase-sensitive and cell permeable, O2-acetoxymethylated diazeniumdiolate that acts as an intracellular nitric oxide (NO) donor (1.83 mol of NO/mol). Shown to induce apoptosis and to act as an antiproliferative agent in NO-sensitive human leukemia HL-60 (IC50 = 8.3 µM) and U937 (IC50 = 53 µM) cell lines. Also suppresses oxidized low-density lipoprotein-induced caspase-3 activation in bovine aortic endothelial cells. Exhibits enhanced stability in physiological buffers. May also be useful for temporal and spatial controlled NO availability.
      Catalogue Number292505
      Brand Family Calbiochem®
      References
      ReferencesKotamraju, S., et al. 2001. J. Biol. Chem. 276, 17316.
      Saavedra, J.E., et al. 2000. J. Med. Chem. 43, 261.
      Product Information
      CAS number213768-16-2
      ATP CompetitiveN
      FormYellow liquid
      Hill FormulaC₇H₁₅N₃O₄
      Chemical formulaC₇H₁₅N₃O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetIntracellular nitric oxide (NO) donor
      Primary Target IC<sub>50</sub>8.3 µM, 53 µM, acting as an antiproliferative agent in NO-sensitive human leukemia HL-60 and U937 cell lines, respectively
      Purity≥95% by NMR
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C. Add to aqueous medium just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      292505-1MG 04055977197945