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260960 DNA-PK Inhibitor - CAS 20357-25-9 - Calbiochem

The DNA-PK Inhibitor, also referenced under CAS 20357-25-9, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DMNB, 4,5-Dimethoxy-2-nitrobenzaldehyde, DNA-Dependent Protein Kinase Inhibitor

Primary Target: DNA-PK activity
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260960
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
20357-25-9C₉H₉NO₅

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260960-10MG
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      Description
      OverviewA cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-PK (DNA-dependent protein kinase) activity (IC50 = 15 µM) and DNA-PK-mediated DSB (double strand break) DNA repair by NHEJ (non-homologous DNA-end-joining). Shown to effectively sensitize cells to killing by Cisplatin (Cat. No. 232120). Does not affect PKC or Chk2 kinase activities.
      Catalogue Number260960
      Brand Family Calbiochem®
      SynonymsDMNB, 4,5-Dimethoxy-2-nitrobenzaldehyde, DNA-Dependent Protein Kinase Inhibitor
      References
      ReferencesWillmore, E., et al. 2004. Blood,103, 4659.
      Durant, S., and Karran, P. 2003. Nucleic Acids Res. 31, 5501.
      Product Information
      CAS number20357-25-9
      ATP CompetitiveN
      FormBright Yellow solid
      Hill FormulaC₉H₉NO₅
      Chemical formulaC₉H₉NO₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDNA-PK activity
      Primary Target IC<sub>50</sub>15 µM against DNA-PK (DNA-dependent protein kinase) activity
      Purity≥90% by GC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      260960-10MG 04055977217544

      Documentation

      DNA-PK Inhibitor - CAS 20357-25-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      DNA-PK Inhibitor - CAS 20357-25-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      260960

      References

      Reference overview
      Willmore, E., et al. 2004. Blood,103, 4659.
      Durant, S., and Karran, P. 2003. Nucleic Acids Res. 31, 5501.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-June-2008 RFH
      SynonymsDMNB, 4,5-Dimethoxy-2-nitrobenzaldehyde, DNA-Dependent Protein Kinase Inhibitor
      DescriptionA cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) activity (IC50 = 15 µM) and DNA-PK-mediated double strand break (DSB) DNA repair by non-homologous DNA-end-joining (NHEJ). Reported to effectively sensitize cells to Cisplatin (Cat. No. 232120). Does not affect the activities of PKC or Chk2.
      FormBright Yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number20357-25-9
      Chemical formulaC₉H₉NO₅
      Structure formulaStructure formula
      Purity≥90% by GC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesWillmore, E., et al. 2004. Blood,103, 4659.
      Durant, S., and Karran, P. 2003. Nucleic Acids Res. 31, 5501.