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23-060M IKKγ

IKKγ MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Enzyme Assays
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23-060M
BULK  
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      Overview

      Key Spec Table

      Key ApplicationsSpeciesCascade Component
      Enzyme AssaysHuman Substrate
      Description
      Catalogue Number23-060M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionIKKγ
      Alternate Names
      • NF-kappa-B essential modulator. Inhibitor of nuclear factor kappa-B kinase subunit gamma
      • FIP-3
      • NEMO
      • IKKg
      Background InformationIKKγ has been shown to play a critical role in NF-κB activation, as the regulatory subunit of IκB kinase, which phosphorylates inhibitors of NF-κB leading to their degradation. Upon cell stimulation, IKKγ can be modified by Lys-63-linked or linear polyubiquitination, both of which are suggested to play key roles in cell signalling, including NF-κB activation. One of the E3 ligases responsible for Lys-63-linked IKKγ polyubiquitination is TRAF6, which participates in several signalling pathways controlling immunity, skin development, osteoclast formation and brain functions.
      Product Information
      Quality LevelMQ100
      Applications
      Key Applications
      • Enzyme Assays
      Biological Information
      Cascade ComponentSubstrate
      Entrez Gene Number
      Purification MethodPurified using glutathione sepharose.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Packaging Information
      Material SizeBULK
      Global Trade Item Number
      Catalogue Number GTIN
      23-060M 04053252959486