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23-059 TRAF6, active

TRAF6, active MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Enzyme Assays
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23-059
10 µg  
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      Overview

      Key Spec Table

      Key ApplicationsSpeciesCascade Component
      Enzyme AssaysHuman E3
      Description
      Catalogue Number23-059
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionTRAF6, active
      Alternate Names
      • TNF receptor-associated factor 6
      • Interleukin-1 signal transducer
      • RING finger protein 85
      Background InformationTRAF6 is a ubiquitin ligase essential for the activation of NF-κB and MAP kinases in multiple signalling pathways including those emanating from the tumour-necrosis-factor receptor (TNFR) and interleukin-1/Toll-like receptors (IL-1R/TLR). TRAF6 also transduces signals from receptors such as CD40 and RANK and may be essential for the formation of functional osteoclasts. Studies indicate that amplification of the TRAF6 locus is a somatic and frequent event in several human cancer types and is a commonly amplified oncogene bridging RAS and NF-κB in lung cancer. Inhibition of TRAF6 in lung cancer cells has been shown to suppress NF-κB activation, anchorage-independent growth and tumour formation.
      Product Information
      Quality LevelMQ100
      Applications
      Key Applications
      • Enzyme Assays
      Biological Information
      Cascade ComponentE3
      Entrez Gene Number
      Purification MethodPurified using glutathione sepharose.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Packaging Information
      Material Size10 µg
      Global Trade Item Number
      Catalogue Number GTIN
      23-059 04053252959530