Millipore Sigma Vibrant Logo

220005 CGP-37157 - CAS 75450-34-9 - Calbiochem

A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC₅₀ = 360 nM).

CGP-37157 - CAS 75450-34-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

Primary Target: Mitochondrial Na+/Ca2+ exchanger
View Products on Sigmaaldrich.com
220005
  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
—
Request Pricing
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

       

      Contact Customer Service

      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      75450-34-9C₁₅H₁₁Cl₂NOS
      Description
      OverviewA cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC50 = 360 nM). Enhances the export of Ca2+ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+ channels.
      Catalogue Number220005
      Brand Family Calbiochem®
      Synonyms7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
      References
      ReferencesJornot, L., et al. 1999. J. Cell Sci. 112, 1013.
      Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833.
      Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295.
      Griffiths, E.J., et al. 1997. Cell Calcium 21, 321.
      White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688.
      Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595.
      Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938.
      Product Information
      CAS number75450-34-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₁₁Cl₂NOS
      Chemical formulaC₁₅H₁₁Cl₂NOS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMitochondrial Na+/Ca2+ exchanger
      Primary Target IC<sub>50</sub>360 nM against mitochondrial Na+/Ca2+ exchanger
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      220005 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      CGP-37157 - CAS 75450-34-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      CGP-37157 - CAS 75450-34-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      220005

      References

      Reference overview
      Jornot, L., et al. 1999. J. Cell Sci. 112, 1013.
      Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833.
      Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295.
      Griffiths, E.J., et al. 1997. Cell Calcium 21, 321.
      White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688.
      Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595.
      Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2013 JSW
      Synonyms7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
      DescriptionA cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC50 = 360 nM). Enhances the export of Ca2+ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+ channels.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number75450-34-9
      Chemical formulaC₁₅H₁₁Cl₂NOS
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml). Dilute in Ca2+-free buffer just prior to use.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJornot, L., et al. 1999. J. Cell Sci. 112, 1013.
      Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833.
      Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295.
      Griffiths, E.J., et al. 1997. Cell Calcium 21, 321.
      White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688.
      Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595.
      Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938.