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219505 CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Ethyl-4-(4ʹ-methoxyphenyl)-thiazolyl-2-amine, CBFα-CBFβ Inhibitor I, CBFβ-Runx1 Inhibitor I

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      493028-20-9C₁₂H₁₄N₂OS
      Description
      Overview

      This product has been discontinued.



      A cell-permeable thiazolyl compound that binds to CBFβ (core binding factor β) and allosterically disrupts CBFα/Runx1 binding to CBFβ both in cell-free binding studies (IC50 of ~3.5 µM by FRET and ELISA) and in HEK293 cells (IC50 of ~ 100 µM by FACS/FRET). Cellular studies indicate a good correlation between the inhibitor's antiproliferative activity and the Runx1 expression level in the target cells.
      Catalogue Number219505
      Brand Family Calbiochem®
      Synonyms5-Ethyl-4-(4ʹ-methoxyphenyl)-thiazolyl-2-amine, CBFα-CBFβ Inhibitor I, CBFβ-Runx1 Inhibitor I
      References
      ReferencesGorczynski, M.J., et al. 2007. Chem. Biol. 14, 1186.
      Product Information
      CAS number493028-20-9
      FormTan solid
      Hill FormulaC₁₂H₁₄N₂OS
      Chemical formulaC₁₂H₁₄N₂OS
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 24/25

      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      219505 0

      Documentation

      CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      219505

      References

      Reference overview
      Gorczynski, M.J., et al. 2007. Chem. Biol. 14, 1186.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms5-Ethyl-4-(4ʹ-methoxyphenyl)-thiazolyl-2-amine, CBFα-CBFβ Inhibitor I, CBFβ-Runx1 Inhibitor I
      DescriptionA cell-permeable thiazolyl compound that binds to CBFβ (core binding factor β) and allosterically disrupts CBFα/Runx1 binding to CBFβ both in cell-free binding studies (IC50 of ~3.5 µM by FRET and ELISA) and in HEK293 cells (IC50 of ~100 µM by FACS/FRET). Cellular studies indicate a good correlation between the inhibitor's antiproliferative activity and the Runx1 expression level in the target cells.
      FormTan solid
      CAS number493028-20-9
      Chemical formulaC₁₂H₁₄N₂OS
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (20 mg/ml) or Ethanol (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGorczynski, M.J., et al. 2007. Chem. Biol. 14, 1186.