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219334 β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem

The β-Catenin/Tcf Inhibitor V, BC21, also referenced under CAS 691005-38-6, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Biochemicals applicat

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Synonyms: Copper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV

219334
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Overview

Key Spec Table

CAS #Empirical Formula
691005-38-6C₃₂H₃₆Cl₂Cu₂N₂O₂

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219334-10MG
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      Description
      OverviewA cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
      Catalogue Number219334
      Brand Family Calbiochem®
      SynonymsCopper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
      References
      ReferencesTian, W., et al. 2012. Biochemistry 51, 724.
      Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
      Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
      Product Information
      CAS number691005-38-6
      FormDark brown solid
      Hill FormulaC₃₂H₃₆Cl₂Cu₂N₂O₂
      Chemical formulaC₃₂H₃₆Cl₂Cu₂N₂O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by Elemental Analysis
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      219334-10MG 04055977202137