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218830 Caspase Inhibitor II, Cell-Permeable - Calbiochem

The Caspase Inhibitor II, Cell-Permeable controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: cpm-VAD-CHO; sequence

Primary Target: caspase-1-like proteases
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218830
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₈₈H₁₅₁N₁₉O₂₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, reversible pan-caspase inhibitor produced by attaching the N-terminal sequence (amino acids 1-16) of the Kaposi fibroblast growth factor signaling peptide, which imparts cell-permeability to VAD peptide.
      Catalogue Number218830
      Brand Family Calbiochem®
      Synonymscpm-VAD-CHO; sequence
      References
      ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Lin, Y-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Lin, Y-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      Product Information
      FormWhite solid
      Hill FormulaC₈₈H₁₅₁N₁₉O₂₂
      Chemical formulaC₈₈H₁₅₁N₁₉O₂₂
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-1-like proteases
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Ala-Asp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      218830 0

      Documentation

      Caspase Inhibitor II, Cell-Permeable - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase Inhibitor II, Cell-Permeable - Calbiochem Certificates of Analysis

      TitleLot Number
      218830

      References

      Reference overview
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Lin, Y-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Lin, Y-Z., et al. 1995. J. Biol. Chem. 270, 14255.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Title
      Xu, J., et al. 2009. The Journal of Neuroscience, 29 9330.
      Carmagnat M., et al. 2006. Oncogene 25, 1914.
      IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-June-2008 RFH
      Synonymscpm-VAD-CHO; sequence
      DescriptionA cell-permeable, reversible inhibitor of caspase-1-like proteases. Constructed by attaching the N-terminal sequence (amino acids 1-16) of the Kaposi fibroblast growth factor signaling peptide to Caspase Inhibitor II (Cat. No. 218735), which imparts cell-permeability to this peptide.
      FormWhite solid
      Chemical formulaC₈₈H₁₅₁N₁₉O₂₂
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Ala-Asp-CHO
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Lin, Y-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Lin, Y-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      CitationXu, J., et al. 2009. The Journal of Neuroscience, 29 9330.
      Carmagnat M., et al. 2006. Oncogene 25, 1914.
      IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.