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203980 α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem

Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings.

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203980
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Overview

Key Spec Table

CAS #Empirical Formula
11032-79-4C₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁

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203980-1MG
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      Description
      OverviewBlocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 µM).
      Catalogue Number203980
      Brand Family Calbiochem®
      References
      ReferencesLopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
      Zhang, Z.W., et al. 1994. Neuron 12, 167.
      Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
      Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
      Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
      Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
      Ruan, K.H., et al. 1990. 87, 6156.
      Product Information
      CAS number11032-79-4
      ATP CompetitiveN
      FormLyophilized solid
      Hill FormulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
      Chemical formulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary TargetMotor end-plate acetylcholine receptor
      Primary Target IC<sub>50</sub>Kd = 1 pM to 1 nM for motor end-plate acetylcholine receptor
      Physicochemical Information
      Cell permeableN
      ContaminantsNone detectable by IEF. Supplied as an acetate salt
      Peptide SequenceH-Ile-Val-Cys³-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹⁶-Pro-Pro-Gly-Glu-Asn-Leu-Cys²³-Tyr-Arg-Lys-Met-Trp-Cys²⁹-Asp-Ala-Phe-Cys³³-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys⁴⁴-Ala-Ala-Thr-Cys⁴⁸-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys⁵⁹-Cys⁶⁰-Ser-Thr-Asp-Lys-Cys⁶⁵-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65)
      Safety Information according to GHS
      RTECSEI6201400
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      203980-1MG 04055977219944