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182800 Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem

An ethyl analog of FK506 with similar immunosuppressant properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Immunomycin, FR-900520

Primary Target: Immunophilins
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      11011-38-4C₄₃H₆₉NO₁₂
      Description
      OverviewAn ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.
      Catalogue Number182800
      Brand Family Calbiochem®
      SynonymsImmunomycin, FR-900520
      References
      ReferencesPaul, C., et al. 2000. Expert Opin. Invest. Drugs 9, 69.
      Kawai, M., et al. 1993. FEBS Lett. 316, 107.
      Pilot-Matias, T.J., et al. 1993. Gene 128, 219.
      Shafiee, A., et al. 1993. J. Antibiot. 46, 1397.
      Petros, A.M., et al. 1992. J. Med. Chem. 35, 2467.
      Product Information
      CAS number11011-38-4
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₄₃H₆₉NO₁₂
      Chemical formulaC₄₃H₆₉NO₁₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityFully active via yeast rotamase (FK 506 binding protein) inhibition
      Primary TargetImmunophilins
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSCI7570000
      Safety Information
      R PhraseR: 20/21/22-36/37/38

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 days at -20°C. Anhydrous DMSO stock solutions are stable for up to 1 month -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      182800 0

      Documentation

      Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      182800

      References

      Reference overview
      Paul, C., et al. 2000. Expert Opin. Invest. Drugs 9, 69.
      Kawai, M., et al. 1993. FEBS Lett. 316, 107.
      Pilot-Matias, T.J., et al. 1993. Gene 128, 219.
      Shafiee, A., et al. 1993. J. Antibiot. 46, 1397.
      Petros, A.M., et al. 1992. J. Med. Chem. 35, 2467.

      Citations

      Title
    • Brian Adams, et al. (2005) A novel class of dual-family immunophilins. Journal of Biological Chemistry 280, 24308-24314.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2008 RFH
      SynonymsImmunomycin, FR-900520
      DescriptionEthyl analog of FK-506 that possesses the same potent immunosuppressive properties as the parent compound. Inhibition of the Ca2+/calmodulin activated phosphatase calcineurin (IC50 = 10 nM) by the ascomycin/FK-506 binding protein complex is believed to be important in the mechanism of immunosuppression. Acts by binding immumophilins.
      FormWhite crystalline solid
      CAS number11011-38-4
      RTECSCI7570000
      Chemical formulaC₄₃H₆₉NO₁₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      Biological activityFully active via yeast rotamase (FK 506 binding protein) inhibition
      SolubilityDMSO (1 mg/ml) or Ethanol (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 days at -20°C. Anhydrous DMSO stock solutions are stable for up to 1 month -20°C.
      Toxicity Harmful
      ReferencesPaul, C., et al. 2000. Expert Opin. Invest. Drugs 9, 69.
      Kawai, M., et al. 1993. FEBS Lett. 316, 107.
      Pilot-Matias, T.J., et al. 1993. Gene 128, 219.
      Shafiee, A., et al. 1993. J. Antibiot. 46, 1397.
      Petros, A.M., et al. 1992. J. Med. Chem. 35, 2467.
      Citation
    • Brian Adams, et al. (2005) A novel class of dual-family immunophilins. Journal of Biological Chemistry 280, 24308-24314.
      		•