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169756 Antithrombin III, Human Plasma - CAS 90170-80-2 - Calbiochem

Antithrombin III, Human Plasma, CAS 90170-80-2, is a single-chain glycoprotein that acts as a principal physiological inhibitor of thrombin.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ATIII, Heparin cofactor, Factor Xa inhibitor

Primary Target: thrombin
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169756
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Overview

Replacement Information

Key Spec Table

CAS #
90170-80-2

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      Description
      OverviewSingle-chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.
      Catalogue Number169756
      Brand Family Calbiochem®
      SynonymsATIII, Heparin cofactor, Factor Xa inhibitor
      References
      ReferencesTsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.
      Product Information
      CAS number90170-80-2
      Unit of DefinitionOne unit is defined as the amount of antithrombin that will inhibit 1.0 unit of human plasma thrombin present in excess. Thrombin activity is measured using 500 µM tosyl-Gly-Pro-Arg-pNA as substrate in 100 mM Tris-HCl at 25°C, pH 8.2
      ATP CompetitiveN
      FormSolid
      FormulationLyophilized from 100 mM sodium citrate buffer, 20 mM Tris-HCl, pH 8.3.
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationAntithrombin III, Human Plasma, CAS 90170-80-2, is a single-chain glycoprotein that acts as a principal physiological inhibitor of thrombin.
      Biological Information
      Primary Targetthrombin
      Puritysingle band by SDS-PAGE
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥5 units/mg protein
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      169756-1MG 04055977207729

      Documentation

      Antithrombin III, Human Plasma - CAS 90170-80-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Antithrombin III, Human Plasma - CAS 90170-80-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      169756

      References

      Reference overview
      Tsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-April-2008 RFH
      SynonymsATIII, Heparin cofactor, Factor Xa inhibitor
      DescriptionSingle chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.
      FormSolid
      FormulationLyophilized from 100 mM sodium citrate buffer, 20 mM Tris-HCl, pH 8.3.
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      CAS number90170-80-2
      Puritysingle band by SDS-PAGE
      Specific activity≥5 units/mg protein
      Unit definitionOne unit is defined as the amount of antithrombin that will inhibit 1.0 unit of human plasma thrombin present in excess. Thrombin activity is measured using 500 µM tosyl-Gly-Pro-Arg-pNA as substrate in 100 mM Tris-HCl at 25°C, pH 8.2
      SolubilityH₂O. Please refer to label for lot-specific volume prior to lyophilization.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesTsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.