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14-779 MKP5, active

MKP5, active MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-779
10 µg  Also available in 250μg size as catalog # 14-779M and in bulk as catalog # 14-779-K.
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      Overview

      Description
      Catalogue Number14-779
      Trade Name
      • Upstate
      DescriptionMKP5, active
      OverviewDual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the
      phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily
      (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members ofthis family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue
      distribution and subcellular localization, and different modes of inducibility of their expression by extracellular
      stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization
      is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various
      tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different
      isoforms have been found for this gene.
      Product Information
      PresentationProtein in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
      Quality LevelMQ100
      Applications
      Key Applications
      • Phosphatase Assay
      Biological Information
      SourceN-terminal 6His-tagged, recombinant, human MKP5, amino acids 320-end, expressed in E. coli.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • DUSP10
      • MKP5
      Purification MethodPurified using Ni2+/NTA agarose.
      UniProt Number
      Molecular Weight20.6 kDa
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by the release of phosphate from the substrate 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250μg size as catalog # 14-779M and in bulk as catalog # 14-779-K.
      Global Trade Item Number
      Catalogue Number GTIN
      14-779 04053252365980