Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
.
Catalogue Number
Ordering Description
Qty/Pack
List
This item has been added to favorites.
Select A Species, Panel Type, Kit or Sample Type
To begin designing your MILLIPLEX® MAP kit select a species, a panel type or kit of interest.
Custom Premix Selecting "Custom Premix" option means that all of the beads you have chosen will be premixed in manufacturing before the kit is sent to you.
Catalogue Number
Ordering Description
Qty/Pack
List
This item has been added to favorites.
Species
Panel Type
Selected Kit
Qty
Catalogue Number
Ordering Description
Qty/Pack
List Price
96-Well Plate
Qty
Catalogue Number
Ordering Description
Qty/Pack
List Price
Add Additional Reagents (Buffer and Detection Kit is required for use with MAPmates)
Qty
Catalogue Number
Ordering Description
Qty/Pack
List Price
48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
This item has been added to favorites.
The Product Has Been Added To Your Cart
You can now customize another kit, choose a premixed kit, check out or close the ordering tool.
126855
Sigma-AldrichAlendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem
An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.
More>>An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
The quantity field is empty. Please enter a quantity of 1 or more to add items to your cart.
Description
Overview
An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). Efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70 µM). Also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).
460 nM against farnesyl diphosphate synthase; ~ 40 - 70 µM as as a broad-spectrum MMP inhibitor; ~ 1 pM against in vitro invasion of prostate cancer cells
Purity
≥98% by titration
Physicochemical Information
Cell permeable
N
Safety Information according to GHS
RTECS
SZ6523500
Safety Information
R Phrase
R: 22;
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Harmful
Storage
+2°C to +8°C
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Global Trade Item Number
Catalogue Number
GTIN
126855-100MG
04055977222142
Documentation
Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem SDS
Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem Certificates of Analysis
Title
Lot Number
126855
References
Reference overview
Lehenkari, P.P., et al. 2002. Mol. Pharmacol.62, 1255. Virtanen, S.S., et al. 2002. Cancer Res.62, 2708. Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys.373, 231. Smith, R., et al. 1971. Lancet1, 945. Fleisch, H., et al. 1969. Nature223, 211.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts. Shown to induce apoptosis of osteoclasts and macrophages. Inhibits farnesyl disphosphate synthase (IC50 = 460 nM with purified enzyme and 1.7 µM with cell extracts). Also shown to inhibit migration, cell adhesion, and invasion of cells (IC50 = 1 pM in prostate cancer cell invasion assays). Efficiently chelates metal ions and functions as a matrix metalloprotease (MMP) inhibitor (IC50 = 40-70 µM).
Form
White solid
CAS number
121268-17-5
RTECS
SZ6523500
Chemical formula
C₄H₁₂NNaO₇P₂ • 3H₂O
Structure formula
Purity
≥98% by titration
Solubility
H₂O (10 mg/ml)
Storage
+2°C to +8°C Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Harmful
Merck USA index
14, 229
References
Lehenkari, P.P., et al. 2002. Mol. Pharmacol.62, 1255. Virtanen, S.S., et al. 2002. Cancer Res.62, 2708. Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys.373, 231. Smith, R., et al. 1971. Lancet1, 945. Fleisch, H., et al. 1969. Nature223, 211.
