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09-278 Anti-20S proteasome subunit β5 Antibody

This Anti-20S proteasome subunit β5 Antibody is validated for use in IH, WB for the detection of 20S proteasome subunit β5.

Anti-20S proteasome subunit β5 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Protein Trafficking Research Sub-Category: Ubiquitin & Ubiquitin Metabolism Gene Symbol: PSMB5, X, LMPX, MGC104214, MB1 UniProt Number: P28074
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09-278
100 µL  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHC, WBRbSerumPolyclonal Antibody
      Description
      Catalogue Number09-278
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-20S proteasome subunit β5 Antibody
      Alternate Names
      • LMP17
      • MB1
      References
      Product Information
      FormatSerum
      Presentation100 µL of purified antiserum preparation in PBS containing 0.09% sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-20S proteasome subunit β5 Antibody is validated for use in IH, WB for the detection of 20S proteasome subunit β5.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to residues 194-207 of human proteasome subunit β5 conjugated to KLH.
      HostRabbit
      SpecificityRecognizes proteasome subunit β5
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit).
      Gene Symbol
      • PSMB5
      • X
      • LMPX
      • MGC104214
      • MB1
      Purification Methodantiserum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P28074 # The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens.
      SIZE: 208 amino acids; 22897 Da
      SUBUNIT: The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure. This subunit can be displaced by the equivalent immune-specific subunit PSMB8. Directly interacts with POMP.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
      SIMILARITY: SwissProt: P28074 ## Belongs to the peptidase T1B family.
      Molecular Weight22 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of shipment for up to 12 months.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      09-278 04053252329722

      Documentation

      Anti-20S proteasome subunit β5 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-20S proteasome subunit β5 Antibody Certificates of Analysis

      TitleLot Number
      Anti-20S proteasome subunit B5 (Rabbit polyclonal IgG) 2896040
      Anti-20S proteasome subunit b5 (Rabbit polyclonal IgG) - 2356118 2356118
      Anti-20S proteasome subunit b5 - NG1723300 NG1723300
      Anti-20S proteasome subunit b5 - NG1812470 NG1812470
      Anti-20S proteasome subunit b5 - NG1879750 NG1879750
      Anti-20S proteasome subunit b5 - NG1883531 NG1883531
      Anti-20S proteasome subunit b5 -2700321 2700321
      Anti-20S proteasome subunit beta;5 - 0611046110 0611046110
      Anti-20S proteasome subunit β5 (Rabbit polyclonal IgG) - 2452694 2452694
      Anti-20S proteasome subunit β5 (Rabbit polyclonal IgG) 3120570
      Show more

      References

      Reference overviewPub Med ID
      The 26S proteasome: subunits and functions
      Tanaka, K and Tsurumi, C
      Mol Biol Rep, 24:3-11 (1997)  1997

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