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06-1115 Anti-Interleukin-18 (IL-18) Antibody

This Anti-Interleukin-18 (IL-18) Antibody is validated for use in WB, IH(P) for the detection of Interleukin-18 (IL-18).

Anti-Interleukin-18 (IL-18) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: IL-18, IL18, IGIF, IL-18, IL1F4, IL-1g UniProt Number: Q14116
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06-1115
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Chp, Rhesus Macaque, PmWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1115
      DescriptionAnti-Interleukin-18 (IL-18) Antibody
      Alternate Names
      • interleukin 18 (interferon-gamma-inducing factor)
      • IL-1 gamma
      • IFN-gamma-inducing factor
      • iboctadekin
      • interleukin-18
      • Interleukin-1 gamma
      • Iboctadekin
      • Interferon gamma-inducing factor
      Background InformationIL-18 has been shown to be a pro-inflammatory cytokine that induces interferon-gamma. IL-18 has also been found to have the ability to activate nuclear factor-kappaB (NFkB), express Fas ligand, induce CC and CXC chemokines, and also has been found to increase the production of viable human immunodeficiency virus. IL-18 has been linked to syndromes displaying symptoms of chronic low-levels of inflammation. IL-18 also seems to have some control over homeostasis and behavior in the central nervous system as well as neuroinflammatory activity.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human tonsil tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Interleukin-18 (IL-18) Antibody is validated for use in WB, IH(P) for the detection of Interleukin-18 (IL-18).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blot (Snap i.d.) Analysis: 5 µg/mL from a previous lot detected IL-18 in 10 µg of human tonsil tissue lysate.

      Immunohistochemistry Analysis: A 1:600 dilution from a previous lot detected IL-18 in normal human spleen tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Interleukin-18.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Chimpanzee
      • Rhesus Macaque
      • Primate
      Species Reactivity NoteDemonstrated to react with human.
      Predicted to react with chimpanzee, rhesus macaque, and primate based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq].
      Gene Symbol
      • IL-18
      • IL18
      • IGIF
      • IL-18
      • IL1F4
      • IL-1g
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

      SUBCELLULAR LOCATION: Secreted.

      SEQUENCE SIMILARITIES: Belongs to the IL-1 family.
      Molecular Weight~22 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human tonsil tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-18 in 10 µg of human tonsil tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      06-1115 04053252377525

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-Interleukin-18 (IL-18) Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Interleukin-18 (IL-18) Antibody Certificates of Analysis

      TitleLot Number
      Anti-Interleukin-18 (IL-18) - 2468168 2468168
      Anti-Interleukin-18 (IL-18) - 1995608 1995608
      Anti-Interleukin-18 (IL-18) - 2273979 2273979
      Anti-Interleukin-18 (IL-18) - 2512109 2512109
      Anti-Interleukin-18 (IL-18) - 3426772 3426772
      Anti-Interleukin-18 (IL-18) - 3506599 3506599
      Anti-Interleukin-18 (IL-18) - 3738075 3738075
      Anti-Interleukin-18 (IL-18) - 4030990 4030990
      Anti-Interleukin-18 (IL-18) - 4047601 4047601
      Anti-Interleukin-18 (IL-18) - NRG1821355 NRG1821355
      Show more

      Brochure

      Title
      Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies