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05-1587 Anti-FOXO3a/FKHRL1 Antibody, clone 15F7.2

Anti-FOXO3a/FKHRL1 Antibody, clone 15F7.2 is a Mouse Monoclonal Antibody for detection of FOXO3a/FKHRL1 also known as Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1 & has been validated in WB & IHC.

Anti-FOXO3a/FKHRL1 Antibody, clone 15F7.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Apoptosis - Additional Gene Symbol: FOXO3, FKHRL1, FOXO3A UniProt Number: O43524
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05-1587
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1587
      Replaces04-1007
      DescriptionAnti-FOXO3a/FKHRL1 Antibody, clone 15F7.2
      Alternate Names
      • Forkhead box protein O3
      • AF6q21 protein
      • Forkhead in rhabdomyosarcoma-like 1
      Background InformationForkhead box protein O3 (FOXO3a), or FKHRL1, is a ubiquitous transcription factor that triggers the expression of pro-apoptotic genes under conditions of oxidative stress. FOXO3a is regulated by the Akt kinase which phosphorylates FOXO3a on serine 253, 315, and on threonine 32 residues. Modified FOXO3a is recognized by the 14-3-3 proteins which export FOXO3a to the cytoplasm, and consequently terminates its transcriptional activity. FOXO3a may also be regulated by lysine methylation in neuronal cells.
      References
      Product Information
      FormatPurified
      Control
      • Rat liver tissue lysate.
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-FOXO3a/FKHRL1 Antibody, clone 15F7.2 is a Mouse Monoclonal Antibody for detection of FOXO3a/FKHRL1 also known as Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1 & has been validated in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:300 dilution from a representative lot detected FOXO3a/FKHRL1 in human thyroid gland tissue and human breast cancer tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human FOX03a.
      Clone15F7.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FOXO3
      • FKHRL1
      • FOXO3A
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~71 kDa observed. An uncharacterized band may be observed at ~28 kDa in some tissue lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in rat liver tissue lysate.

      Western Blot Analysis: 0.2 µg/mL of this antibody detected FOXO3a/FKHRL1 in 10 mg of rat liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      05-1587 04053252597756

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-FOXO3a/FKHRL1 Antibody, clone 15F7.2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-FOXO3a/FKHRL1 Antibody, clone 15F7.2 Certificates of Analysis

      TitleLot Number
      Anti-FOXO3a/FKHRL1, clone 15F7.2 - 2379498 2379498
      Anti-FOXO3a/FKHRL1, clone 15F7.2 - 2276373 2276373
      Anti-FOXO3a/FKHRL1, clone 15F7.2 - 2287779 2287779
      Anti-FOXO3a/FKHRL1, clone 15F7.2 - 3152159 3152159
      Anti-FOXO3a/FKHRL1, clone 15F7.2 - 3561575 3561575
      Anti-FOXO3a/FKHRL1, clone 15F7.2 - Q2025110 Q2025110
      Anti-FOXO3a/FKHRL1, clone 15F7.2 -2857487 2857487

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies