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04-1583 Anti-Interleukin 21 (IL-21) Antibody, clone 1G8

This Anti-Interleukin 21 (IL-21) Antibody, clone 1G8 is validated for use in WB, ELISA for the detection of Interleukin 21 (IL-21).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: Za11, IL-21, IL21 UniProt Number: Q9HBE4
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04-1583
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ELISAMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-1583
      DescriptionAnti-Interleukin 21 (IL-21) Antibody, clone 1G8
      Alternate Names
      • interleukin 2
      • interleukin-2
      • interleukin-21 isoform
      Background InformationInterleukin 21 (IL-21) is a cytokine that has immunoregulatory activity on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. IL-21 induces cell division/proliferation in its target cells and is expressed in activated human CD4+ T cells. IL-21 may promote the transition between innate and adaptive immunity and may play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. IL-21 expression is up-regulated in Th2 and Th17 subsets of T helper cells, as well as follicular T cells. Furthermore IL-21 is expressed in NK T cells regulating the function of these cells. IL-21 is also produced by Hodgkin's lymphoma (HL) cancer cells and may explain a great deal of the behavior of classical Hodgkin's lymphoma including clusters of other immune cells gathered around HL cells in cultures.
      References
      Product Information
      FormatPurified
      Control
      • Human IL-21 recombinant protein
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Interleukin 21 (IL-21) Antibody, clone 1G8 is validated for use in WB, ELISA for the detection of Interleukin 21 (IL-21).
      Key Applications
      • Western Blotting
      • ELISA
      Application NotesELISA Analysis: A previous lot was used by an independent laboratory in ELISA. (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX)
      Biological Information
      ImmunogenFull length recombinant protein corresponding to human IL-21.
      CloneAB43.50.32H5.1G8
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Za11
      • IL-21
      • IL21
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells By similarity. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

      SUBCELLULAR LOCATION: Secreted

      TISSUE SPECIFICITY: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.

      SEQUENCE SIMLARITIES: Belongs to the IL-15/IL-21 family.

      SEQUENCE CAUTION: The sequence AAG29348.1 differs from that shown. Reason: Erroneous initiation.

      The sequence AAH66258.1 differs from that shown. Reason: Erroneous initiation.

      The sequence AAH66259.1 differs from that shown. Reason: Erroneous initiation.

      The sequence AAH66260.1 differs from that shown. Reason: Erroneous initiation.

      The sequence AAH66261.1 differs from that shown. Reason: Erroneous initiation.

      The sequence AAH66262.1 differs from that shown. Reason: Erroneous initiation.

      The sequence AAH69124.1 differs from that shown. Reason: Erroneous initiation.

      The sequence AAU88182.1 differs from that shown. Reason: Erroneous initiation.

      The sequence ABG36529.1 differs from that shown. Reason: Erroneous initiation.
      Molecular WeightTwo isoforms are observed at ~16 and ~18 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot from human IL-21 recombinant protein.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-21 on 10 µg of human IL-21 recombinant protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      04-1583 04053252749643

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-Interleukin 21 (IL-21) Antibody, clone 1G8 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Interleukin 21 (IL-21) Antibody, clone 1G8 Certificates of Analysis

      TitleLot Number
      Anti-Interleukin 21 (IL-21), clone 1G8 - 2383184 2383184
      Anti-Interleukin 21 (IL-21), clone 1G8 - 2420498 2420498
      Anti-Interleukin 21 (IL-21), clone 1G8 - 2452662 2452662
      Anti-Interleukin 21 (IL-21), clone 1G8 - 2224491 2224491
      Anti-Interleukin 21 (IL-21), clone 1G8 - 2291739 2291739
      Anti-Interleukin 21 (IL-21), clone 1G8 - 2360020 2360020
      Anti-Interleukin 21 (IL-21), clone 1G8 - 3275068 3275068
      Anti-Interleukin 21 (IL-21), clone 1G8 - 3307793 3307793
      Anti-Interleukin 21 (IL-21), clone 1G8 - 3502155 3502155
      Anti-Interleukin 21 (IL-21), clone 1G8 - 3706687 3706687
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      Brochure

      Title
      Advancing cancer research: From hallmarks & biomarkers to tumor microenvironment progression

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies