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04-1470 Anti-OX40L (CD252) Antibody, clone RM134L

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04-1470
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, IHCRPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-1470
      DescriptionAnti-OX40L (CD252) Antibody, clone RM134L
      Alternate Names
      • Tumor necrosis factor ligand superfamily member 4
      • OX40 ligand
      • OX40L
      • CD252
      Background InformationOX40L (Tumor necrosis factor ligand superfamily member 4; or CD252) is the endogenous ligand of the OX40 receptor. OX40 is localized on activated T-cells and propagates the immune response by promoting division and survival of T-cells, thereby increasing the population of memory CD4 and CD8 T cells produced in response to antigen detection. The OX40/OX40L may also regulate cytokine production and suppress the activity of T-regulatory cells. OX40/OX40L is therefore an important mediator of the immune response. Previous studies have suggested that OX40 signaling maybe involved in the development of autoimmune diseases.
      References
      Product Information
      FormatPurified
      Control
      • Mouse OX40L/L5178Y cells
      PresentationPurified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-OX40L (CD252) Antibody, clone RM134L detects level of OX40L (CD252) & has been published & validated for use in Flow Cytometry & IHC.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A representative lot was used by an independent laboratory in mouse lung tissue. (Hoshino, A., et al. (2003). Eur. J. Immunol. 33:861–869.)
      Biological Information
      ImmunogenMouse OX40L cDNA-transfected NRK cells
      EpitopeExtracellular domain
      CloneRM134L
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificityThis antibody recognizes the extracellular domain of OX40L.
      IsotypeIgG2bκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Tnfsf4
      • Ox40l
      • Txgp1l
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

      SUBUNIT STRUCTURE: Homotrimer.

      SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.

      SEQUENCE SIMILARITIES: Belongs to the tumor necrosis factor family.
      Molecular Weight22 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in mouse OX40L/L5178Y cells.

      Flow Cytometry Analysis: 10 µg of this antibody detected OX40L in mouse OX40L/L5178Y cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      04-1470 04053252549670

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-OX40L (CD252) Antibody, clone RM134L SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-OX40L (CD252) Antibody, clone RM134L Certificates of Analysis

      TitleLot Number
      Anti-OX40L (CD252), clone RM134L 2774072
      Anti-OX40L (CD252), clone RM134L - 2394055 2394055
      Anti-OX40L (CD252), clone RM134L - 3204272 3204272
      Anti-OX40L (CD252), clone RM134L - 3318620 3318620
      Anti-OX40L (CD252), clone RM134L - 4119037 4119037
      Anti-OX40L (CD252), clone RM134L - Q1996116 Q1996116
      Anti-OX40L (CD252), clone RM134L -2668443 2668443
      Anti-OX40L (CD252), clone RM134L Monoclonal Antibody 3067520
      Anti-OX40L (CD252), clone RM134L Monoclonal Antibody 3115960

      References

      Reference overviewPub Med ID
      Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma.
      Hoshino, Akihiko, et al.
      Eur. J. Immunol., 33: 861-9 (2003)  2003

      Show Abstract
      12672051 12672051

      Brochure

      Title
      New Products: Volume 3, 2012