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MABN353 Anti-DOCK8 Antibody, clone 10C3.2

Anti-DOCK8 Antibody, clone 10C3.2 is an antibody against DOCK8 for use in Western Blotting, Flow Cytometry.

Anti-DOCK8 Antibody, clone 10C3.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: DOCK8 UniProt Number: Q8NF50
MABN353
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, FCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN353
      DescriptionAnti-DOCK8 Antibody, clone 10C3.2
      Alternate Names
      • DOCK8
      • Dedicator of cytokinesis protein 8
      Background InformationDedicator of cytokinesis protein 8 (also known as 1200017A24Rik or Epididymis luminal protein 205) is encoded by the DOCK8 gene (also known as HEL-205, MRD2, ZIR8) in human (NCBI Gene ID 81704). DOCK8 is a cytosolic scaffolding protein involved in cytoskeletal rearrangement and cell migration. DOCK8 deficiency due to genetic mutations result in combined immune deficiency, historically diagnosed as an atypical form of hyper-IgE syndrome (HIES) or autosomal recessive HIES, which remains to be the focus of ongoing DOCK8 research activities. (PMIDn20864884). Clone 10C3.2 detects an internal epitope within the C-terminal half of the DOCK8 protein (UniProt Q8NF50).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-DOCK8 Antibody, clone 10C3.2 is an antibody against DOCK8 for use in Western Blotting, Flow Cytometry.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 2.5 µg of this antibody from a representative lot detected DOCK8 in cycling T cells (Dr's. Qian Zhang and Helen Su).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human DOCK8.
      Clone10C3.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DOCK8
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~230 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in EBV transformed B lymphoblastoid cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected DOCK8 in 10 µg of EBV transformed B lymphoblastoid cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN353 04055977162714