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MABN1537 Anti-TDO2 Antibody, clone 7A6.1

Anti-TDO2, clone 7A6.1, Cat. No. MABN1537, is a highly specific mouse monoclonal antibody that targets TDO2, validated for use in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-TDO2 Antibody, clone 7A6.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: TDO2, TDO UniProt Number: P48775
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MABN1537
200 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1537
      DescriptionAnti-TDO2 Antibody, clone 7A6.1
      Alternate Names
      • Tryptophan 2
      • 3-dioxygenase
      • TDO
      • TO
      • TRPO
      • Tryptamin 2
      • 3-dioxygenase
      • Tryptophan oxygenase
      • Tryptophan pyrrolase
      • Tryptophanase
      Background InformationTryptophan 2,3-dioxygenase (EC 1.13.11.11; UniProt P48775; also known as TDO, TO, TRPO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, Tryptophan pyrrolase, Tryptophanase) is encoded by the TDO2 (also known as TDO) gene (Gene ID 6999) in human. TDO2 is a cytosolic heme-containing enzyme that exists as a homotetramer, where the N terminal residues of each monomer form part of the substrate binding site in an adjacent monomer. Tryptophan 2,3-dioxygenase (TDO2) catalyzes the first step of the kynurenine pathway, namely the conversion of tryptophan to kynurenine (Kyn), which can also be catalyzed by indoleamine 2,3-dioxygenase 1 (IDO1) or IDO2. IDO1 is expressed in tissues throughout the body, while TDO2 is predominantly expressed in the liver. Altered tryptophan metabolism and increased secretion of tryptophan metabolites are found in solid tumors, including in breast cancer. TDO2-mediated Kyn production in triple-negative breast cancer (TNBC) cells is reported to activate aryl hydrocarbon receptor (AhR), an endogenous kynurenine receptor. Inhibiting TDO2 or AhR via pharmacologic or genetic means is reported to result in increased sensitivity to anoikis, as well as decreased proliferation, migration, and invasion of TNBC cells.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4) 150 mM NaCl with 0.05% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationAnti-TDO2, clone 7A6.1, Cat. No. MABN1537, is a highly specific mouse monoclonal antibody that targets TDO2, validated for use in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TDO2 in human kidney, liver, and small intestine tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant human TDO2 internal fragment.
      Clone7A6.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 7A6.1 targets an internal epitope of human and murine TDO2 (TDO).
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TDO2
      • TDO
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~48 kDa observed. 47.87 kDa (human) and 47.76 kDa (mouse) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse liver tissue lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected TDO2 in 10 µg of mouse liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN1537 04054839035326

      Documentation

      Anti-TDO2 Antibody, clone 7A6.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-TDO2 Antibody, clone 7A6.1 Certificates of Analysis

      TitleLot Number
      Anti-TDO2, clone 7A6.1 - 3862597 3862597
      Anti-TDO2, clone 7A6.1 - 4090085 4090085
      Anti-TDO2, clone 7A6.1 -Q2724519 Q2724519
      Anti-TDO2, clone 7A6.1 Monoclonal Antibody 3013238
      Anti-TDO2, clone 7A6.1 Monoclonal Antibody 3156740
      Anti-TDO2, clone 7A6.1 Monoclonal Antibody 2909986
      Anti-TDO2, clone 7A6.1 Monoclonal Antibody 2933154
      Anti-TDO2, clone 7A6.1 Monoclonal Antibody 3083565