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MABN1191 Anti-Parvalbumin Antibody, clone 4E9.2

This Anti-Parvalbumin Antibody, clone 4E9.2 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Parvalbumin.

Anti-Parvalbumin Antibody, clone 4E9.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Synapse & Synaptic Biology Gene Symbol: Pvalb, Pva UniProt Number: P02625
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MABN1191
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1191
      DescriptionAnti-Parvalbumin Antibody, clone 4E9.2
      Alternate Names
      • Parvalbumin alpha
      • Parvalbumin
      • PV
      Background InformationParvalbumin alpha (UniProt P02625; also known as PV) is encoded by the Pvalb (also known as Pva) gene (Gene ID 25269) in rat species. Parvalbumin alpha is a small (a.a. 2-110; Met1 removed posttranslationally) calcium-binding protein. Parvalbumin alpha is composed almost entirely of two EF-hand domains (a.a. 39-74 & 78-110) and is structurally related to calmodulin and troponin C. Parvalbumin (PV) is present in GABAergic interneurons in the nervous system, especially the reticular thalamus. PV interneurons are a subset of inhibitory GABAergic neurons that control the excitability of post-synaptic pyramidal neurons. Dysfunction or loss of PV interneurons is implicated in cognitive deficits associated with a number of well known psychiatric disorders, including schizophrenia, Alzheimer’s disease, and depression.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1 antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Parvalbumin Antibody, clone 4E9.2 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Parvalbumin.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Parvalbumin in human kidney, rat kidney, and mouse cerebral cortex tissue sections.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of rat parvalbumin.
      EpitopeInternal (N-terminal half).
      Clone4E9.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 4E9.2 detects an epitope conserved among human, mouse, and rat species.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteHuman, Mouse, Rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Pvalb
      • Pva
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~12 kDa observed. 11.93 kDa (human), 11.80 kDa (mouse), 11.79 kDa (rat) calculated (Met1 removed). Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.

      Western Blotting Analysis: 0.25 µg/mL of this antibody detected Parvalbumin in 10 µg of mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN1191 04055977352993