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MABC1019 Anti-STK24 Antibody, clone 4D2.1

This Anti-STK24 Antibody, clone 4D2.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of STK24.

Anti-STK24 Antibody, clone 4D2.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: STK24, MST3, STK3 UniProt Number: Q9Y6E0
MABC1019
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC1019
      DescriptionAnti-STK24 Antibody, clone 4D2.1
      Alternate Names
      • Serine/threonine-protein kinase 24
      • Mammalian STE20-like protein kinase 3
      • MST-3, STE20-like kinase MST3
      Background InformationSerine/threonine-protein kinase 24 (EC 2.7.11.1; UniProt Q9Y6E0; also known as Mammalian STE20-like protein kinase 3, MST-3, STE20-like kinase MST3) is encoded by the STK24 (also known as MST3, STK3) gene (Gene ID 8428) in human. STK24 (MST3) is a member of the highly conserved family of Ste20-like kinases. MST3 is regulated by several posttranslational modifcation events. Autophosphorylation of a threonine residue in the N-terminal kinase domain (a.a. 36-286) is reported to result in autoactivation. and the dephosphorylation of a threonine residue in the C-terminal regulatory domain is shown to promote its binding to the scaffolding protein MO25. In addition, MST3 is known to be cleaved by caspase activity into a 12 kDa C-terminal fragment (a.a.326-443) and a kinase domain-containing 36 kDa N-terminal fragment (a.a. 1-325), which then translocates from the cytoplasm to the nucleus. MST3 is expressed ubiquitously in various tissues including the brain, where it plays an important role in the formation and maintenance of dendritic architecture.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-STK24 Antibody, clone 4D2.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of STK24.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected STK24 in normal human cerebral cortex and small intestine, as well as human colon cancer tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to an internal fragment from the C-terminal half of human STK24.
      EpitopeInternal (C-terminal half).
      Clone4D2.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with both spliced isoforms reported by UniProt (Q9Y6E0). Reactivity toward the posttranslationally cleaved N-terminal 36 kDa subunit (a.a. 1-325) and the C-terminal 12 kDa subunit (a.a. 326-443) has not been determined.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • STK24
      • MST3
      • STK3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~55 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Raji cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected STK24 in 200 µg of Raji cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC1019 04055977314922