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ABN242 Anti-Pannexin-1/PANX1 Antibody

Anti-Pannexin-1/PANX1 Antibody is an antibody against Pannexin-1/PANX1 for use in Western Blotting, Immunohistochemistry.

Anti-Pannexin-1/PANX1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Signaling Neuroscience Gene Symbol: PANX1, MRS1, PX1 UniProt Number: Q96RD7
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ABN242
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN242
      ReplacesAB9886
      DescriptionAnti-Pannexin-1/PANX1 Antibody
      Alternate Names
      • Pannexin-1
      • Innexin
      Background InformationPannexin-1 (UniProt Q96RD7; also known as Innexin) is encoded by the PANX1 (also known as MRS1, PX1) gene (ORF UNQ2529/PRO6028; Gene ID 24145) in human. Pannexin 1 is a high-conductance, voltage-gated channel protein widely expressed in many organs and tissues, including the sensory systems (eye, inner ear, taste buds, and the olfactory epithelium) and both neuronal and non-neuronal cell types. Three pannexin family genes (PANX1-3) have been identified in human and mouse genomes. Pannexin proteins share structural and functional similarities and play important roles in many physiological and pathological processes, such as ATP release, Ca2+ homeostasis, synaptic neurotransmitters release, apoptosis, and immunological response. Pannexin-1 deficiency causes caspase-3 activation and apoptosis induction of hair cells in cochlear spiral limbus (SLM), resulting in hearing loss among Panx1-/- mice. Panx1 is also expressed in the retina, lens and cornea of the eye, where it plays an important role in mediating the crosstalk between immune and neuronal cells. Pannexin-1 channel opening, frequently together with the activation of purinergic receptors by extracellular ATP, is reported to have a great implication in diverse pathological conditions, including ischemia, trauma, HIV infection, inflammation, migraine, and cancer cell growth.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Pannexin-1/PANX1 Antibody is an antibody against Pannexin-1/PANX1 for use in Western Blotting, Immunohistochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Pannexin-1/PANX1 in human testis and mouse kidney tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant human Pannexin-1/PANX1 C-terminal fragment.
      EpitopeC-terminal
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityExpected to react with both spliced isoforms reported by UniProt (Q96RD7-1 & Q96RD7-2).
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteHuman, Mouse, Rat. Predicted to react with Chimpanzee, Gorilla based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PANX1
      • MRS1
      • PX1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~55 kDa observed. 55-58 kDa (membrane glycosylated) and 43 kDa (cytosolic non-glycosylated) expected. 48.1 kDa (isoform 1) & 47.6 kDa (isoform 2) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human cortex tissue lysate.

      Western Blotting Analysis: 0.1 µg/mL of this antibody detected Pannexin-1/PANX1 in 10 µg of human cortex tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN242 04055977312539

      Documentation

      Anti-Pannexin-1/PANX1 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Pannexin-1/PANX1 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Pannexin-1/PANX1 - 3423492 3423492
      Anti-Pannexin-1/PANX1 - 3584359 3584359
      Anti-Pannexin-1/PANX1 - 3686320 3686320
      Anti-Pannexin-1/PANX1 - 3764391 3764391
      Anti-Pannexin-1/PANX1 - 4144913 4144913
      Anti-Pannexin-1/PANX1 -Q2638543 Q2638543
      Anti-Pannexin-1/PANX1 Polyclonal Antibody 3150363

      Brochure

      Title
      Neuroscience Solutions for productive research