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AB5701-I Anti-Slit2 Antibody, C-term

Anti-Slit2, C-term, Cat. No. AB5701-I, is a highly specific rabbit polyclonal antibody that targets Slit2 and has been tested in Western Blotting.

Anti-Slit2 Antibody, C-term MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: SLIT2, SLIL3 UniProt Number: O94813
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AB5701-I
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5701-I
      ReplacesAB5701
      DescriptionAnti-Slit2 Antibody, C-term
      Alternate Names
      • Slit homolog 2 protein
      • Slit-2
      • Slit2
      Background InformationSlit homolog 2 protein (UniProt O94813; also known as Slit-2, Slit2) is encoded by the SLIT2 (also known as SLIL3) gene (Gene ID 9353) in human. Slit proteins are essential for midline guidance in the forebrain where they act as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Slit-2 acts as molecular guidance cue in cellular migration and its function appears to be mediated by interaction with roundabout homolog receptors. During neural development it is involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. In the developing visual system it appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. Ref.: Niclou, SP., et al. (2000) J Neurosci. 20; 4962-4974.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Slit2, C-term, Cat. No. AB5701-I, is a highly specific rabbit polyclonal antibody that targets Slit2 and has been tested in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a sequence within the CTCK domain of human Slit-2.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody targets region within the CTCK domain (a.a. 1453-1528) ane will therefore react with uncleaved Slit-2 and cleaved Slit-2 C-product (a.a. 1122-1529), but not the cleaved N-product (a.a. 31-1121).
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLIT2
      • SLIL3
      Purification MethodAffinity purified.
      UniProt Number
      Molecular Weight~180 kDa observed. 166.8/166.3/165.8 kDa (isoform 1/2/3 without signal peptide a.a. 1-30) and 44.52 kDa (C-product) calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in U2OS cell lysate.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected Slit-2 in 10 µg of U2OS cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5701-I 04054839092121