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23-056M XIAP, active

XIAP, active MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Enzyme Assays Entrez Gene Number: NM_001167
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23-056M
250 µg  
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      Overview

      Description
      Catalogue Number23-056M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionXIAP, active
      Alternate Names
      • Baculoviral IAP repeat-containing protein 4 (BIRC4)
      • IAP-like protein
      • Inhibitor of apoptosis protein 3 (API3)
      Background InformationX-linked inhibitor of apoptosis (XIAP) is one of a group of intracellular proteins which have been shown to act as endogenous inhibitors of caspases, the enzymatic effectors of apoptosis. XIAP possesses a C-terminal RING domain that functions as an E3 ubiquitin ligase and is able to ubiquitinate a variety of substrates thereby affecting a broad range of cellular activities beyond apoptotic suppression. There is evidence that XIAP plays a significant role in cell division, morphogenesis, heavy metal homeostasis, NF-kB activation and MAP kinase signalling. XIAP expression has been shown to be elevated in several malignancies and so is considered a promising target in anticancer therapies.
      Product Information
      Quality LevelMQ100
      Applications
      Key Applications
      • Enzyme Assays
      Biological Information
      Cascade ComponentE3
      Entrez Gene Number
      Purification MethodPurified using glutathione sepharose, followed by gel filtration
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Packaging Information
      Material Size250 µg
      Global Trade Item Number
      Catalogue Number GTIN
      23-056M 04053252919053